Literature DB >> 12801284

Interleukin-4-expressing plasmid DNA inhibits reovirus type-2-triggered autoimmune insulitis in DBA/1 J suckling mice.

T Hayashi1, Y Yasutomi, K Hasegawa, Y Sasaki, T Onodera.   

Abstract

In this study we have examined the effect of systemic administration of T helper (Th) 2 cytokines on reovirus type-2 (Reo-2)-triggered Th1-mediated autoimmune insulitis with impaired glucose tolerance (IGT) in DBA/1J suckling mice. We have demonstrated clearly that the systemic administration of both interleukin (IL)-4-expressing plasmid DNA (pIL-4) and recombinant IL-4 (rIL-4) inhibited the development of insulitis with IGT in a dose dependent manner as compared to untreated groups in Reo-2-infected DBA/1J suckling mice. The inhibitory effects of IL-4 on the development of insulitis with IGT and the advantages of pIL-4 as compared to rIL-4 in this model are discussed.

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Year:  2003        PMID： 12801284      PMCID： PMC2517546          DOI： 10.1046/j.1365-2613.2003.00341.x

Source DB:  PubMed          Journal:  Int J Exp Pathol        ISSN： 0959-9673            Impact factor:   1.925


  31 in total

Review 1.  TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

Authors:  T R Mosmann; R L Coffman
Journal:  Annu Rev Immunol       Date:  1989       Impact factor: 28.527

2.  Serological relationship between Japanese strains of reovirus of bovine origin and type 2 reovirus strains.

Authors:  H Kurogi; Y Inaba; E Takahashi; K Sato; T Omori
Journal:  Natl Inst Anim Health Q (Tokyo)       Date:  1980

3.  Direct gene transfer into mouse muscle in vivo.

Authors:  J A Wolff; R W Malone; P Williams; W Chong; G Acsadi; A Jani; P L Felgner
Journal:  Science       Date:  1990-03-23       Impact factor: 47.728

4.  Reovirus type 2-induced diabetes in mice prevented by immunosuppression and thymic hormone.

Authors:  T Onodera; T Taniguchi; K Yoshihara; S Shimizu; M Sato; T Hayashi
Journal:  Diabetologia       Date:  1990-04       Impact factor: 10.122

5.  Viruses and cytokines: evidence for multiple roles in pancreatic beta cell destruction in type 1 insulin-dependent diabetes mellitus.

Authors:  I L Campbell; L C Harrison
Journal:  J Cell Biochem       Date:  1989-05       Impact factor: 4.429

Review 6.  Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?

Authors:  A Rabinovitch
Journal:  Diabetes       Date:  1994-05       Impact factor: 9.461

7.  Plasmid encoding interferon-gamma exacerbates reovirus type-2-induced diabetes in DBA/1 suckling mice.

Authors:  K Hasegawa; T Hayashi; K Maeda; T Onodera
Journal:  J Comp Pathol       Date:  2002 Aug-Oct       Impact factor: 1.311

8.  Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

Authors:  R Manetti; P Parronchi; M G Giudizi; M P Piccinni; E Maggi; G Trinchieri; S Romagnani
Journal:  J Exp Med       Date:  1993-04-01       Impact factor: 14.307

9.  Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

Authors:  M J Rapoport; A Jaramillo; D Zipris; A H Lazarus; D V Serreze; E H Leiter; P Cyopick; J S Danska; T L Delovitch
Journal:  J Exp Med       Date:  1993-07-01       Impact factor: 14.307
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