Literature DB >> 1280109

Brain nitric oxide synthase is a haemoprotein.

P Klatt1, K Schmidt, B Mayer.   

Abstract

Brain nitric oxide (NO) synthase showed pyridine haemochrome spectra typical of ferroprotoporphyrin IX-containing enzymes. The haem content of purified NO synthase was in the range 0.7-0.9 mol/mol of 160 kDa subunit. In the presence of CO, NO, KCN and miconazole, the L-citrulline-forming activity of NO synthase was markedly diminished, demonstrating that enzyme-bound haem is involved in enzymic NO synthesis.

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Year:  1992        PMID： 1280109      PMCID： PMC1132072          DOI： 10.1042/bj2880015

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

1.  Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

Authors:  D S Bredt; C D Ferris; S H Snyder
Journal:  J Biol Chem       Date:  1992-06-05       Impact factor: 5.157

2.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

Review 3.  P450BM-3 and other inducible bacterial P450 cytochromes: biochemistry and regulation.

Authors:  A J Fulco
Journal:  Annu Rev Pharmacol Toxicol       Date:  1991       Impact factor: 13.820

4.  Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

Authors:  D S Bredt; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

Review 5.  Isoforms of nitric oxide synthase. Characterization and purification from different cell types.

Authors:  U Förstermann; H H Schmidt; J S Pollock; H Sheng; J A Mitchell; T D Warner; M Nakane; F Murad
Journal:  Biochem Pharmacol       Date:  1991-10-24       Impact factor: 5.858

6.  Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins.

Authors:  J L Boucher; A Genet; S Vadon; M Delaforge; D Mansuy
Journal:  Biochem Biophys Res Commun       Date:  1992-05-15       Impact factor: 3.575

7.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

8.  Biosynthesis of endothelium-derived relaxing factor: a cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase.

Authors:  B Mayer; K Schmidt; P Humbert; E Böhme
Journal:  Biochem Biophys Res Commun       Date:  1989-10-31       Impact factor: 3.575

9.  Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in Bacillus megaterium.

Authors:  L O Narhi; A J Fulco
Journal:  J Biol Chem       Date:  1986-06-05       Impact factor: 5.157

10.  Simultaneous determination of hemes a, b, and c from pyridine hemochrome spectra.

Authors:  E A Berry; B L Trumpower
Journal:  Anal Biochem       Date:  1987-02-15       Impact factor: 3.365
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  23 in total

Review 1.  NO as a signalling molecule in the nervous system.

Authors:  Juan V Esplugues
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

Review 2.  Nitric oxide synthases in mammals.

Authors:  R G Knowles; S Moncada
Journal:  Biochem J       Date:  1994-03-01       Impact factor: 3.857

3.  Subcellular localization and characterization of nitric oxide synthase(s) in endothelial cells: physiological implications.

Authors:  M Hecker; A Mülsch; E Bassenge; U Förstermann; R Busse
Journal:  Biochem J       Date:  1994-04-01       Impact factor: 3.857

4.  Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.

Authors:  Huiying Li; Jotaro Igarashi; Joumana Jamal; Weiping Yang; Thomas L Poulos
Journal:  J Biol Inorg Chem       Date:  2006-06-28       Impact factor: 3.358

5.  L-NNA inhibits the histochemical NADPH-d reaction in rat spinal cord neurons.

Authors:  D Blottner; H G Baumgarten
Journal:  Histochem Cell Biol       Date:  1995-05       Impact factor: 4.304

Review 6.  In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide.

Authors:  B Mayer; E R Werner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-05       Impact factor: 3.000

7.  Inhibition of nitric oxide synthase activity in cerebral cortical synaptosomes by nitric oxide donors: evidence for feedback autoregulation.

Authors:  T W Vickroy; W L Malphurs
Journal:  Neurochem Res       Date:  1995-03       Impact factor: 3.996

8.  High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli.

Authors:  L J Roman; E A Sheta; P Martasek; S S Gross; Q Liu; B S Masters
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-29       Impact factor: 11.205

9.  Interaction of nitric oxide and cyclic guanosine 3',5'-monophosphate in erythropoietin production.

Authors:  T Ohigashi; J Brookins; J W Fisher
Journal:  J Clin Invest       Date:  1993-09       Impact factor: 14.808

10.  Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase.

Authors:  Kirsty Knight; Nigel S Scrutton
Journal:  Biochem J       Date:  2002-10-01       Impact factor: 3.857
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