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Literature DB >> 1280104

Evolutionary conservation of the dystrophin central rod domain.

Abstract

Dystrophin cDNA fragments encoding the C-terminal repeats of the central rod region have been expressed as fusion proteins. The polyclonal antisera raised to the purified fusion proteins have been characterized and neither antiserum cross-reacted with dystrophin-related protein. Antisera detected dystrophin with molecular mass close to that of the human in all terrestrial vertebrates and amphibia studied. Experiments with antisera to the N-terminal region of the dystrophin rod confirmed that epitopes to the rod region were conserved during this evolutionary period and the length of this domain remained unaltered.

Entities: Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1280104 PMCID： PMC1133072 DOI： 10.1042/bj2870755

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

24 in total

1. Very mild muscular dystrophy associated with the deletion of 46% of dystrophin.

Authors: S B England; L V Nicholson; M A Johnson; S M Forrest; D R Love; E E Zubrzycka-Gaarn; D E Bulman; J B Harris; K E Davies
Journal: Nature Date: 1990-01-11 Impact factor: 49.962

2. Dystrophin and nebulin in the muscular dystrophies.

Authors: K Patel; T Voit; M J Dunn; P N Strong; V Dubowitz
Journal: J Neurol Sci Date: 1988-11 Impact factor: 3.181

3. Diagnostic needle muscle biopsy. A practical and reliable alternative to open biopsy.

Authors: J Z Heckmatt; A Moosa; C Hutson; C A Maunder-Sewry; V Dubowitz
Journal: Arch Dis Child Date: 1984-06 Impact factor: 3.791

4. Dystrophin: the protein product of the Duchenne muscular dystrophy locus.

Authors: E P Hoffman; R H Brown; L M Kunkel
Journal: Cell Date: 1987-12-24 Impact factor: 41.582

5. Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse.

Authors: D R Love; G E Morris; J M Ellis; U Fairbrother; R F Marsden; J F Bloomfield; Y H Edwards; C P Slater; D J Parry; K E Davies
Journal: Proc Natl Acad Sci U S A Date: 1991-04-15 Impact factor: 11.205

6. An autosomal transcript in skeletal muscle with homology to dystrophin.

Authors: D R Love; D F Hill; G Dickson; N K Spurr; B C Byth; R F Marsden; F S Walsh; Y H Edwards; K E Davies
Journal: Nature Date: 1989-05-04 Impact factor: 49.962

7. The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein.

Authors: M Koenig; A P Monaco; L M Kunkel
Journal: Cell Date: 1988-04-22 Impact factor: 41.582

8. Alternative splicing of human dystrophin mRNA generates isoforms at the carboxy terminus.

Authors: C A Feener; M Koenig; L M Kunkel
Journal: Nature Date: 1989-04-06 Impact factor: 49.962

9. Differentiation of Duchenne and Becker muscular dystrophy phenotypes with amino- and carboxy-terminal antisera specific for dystrophin.

Authors: D E Bulman; E G Murphy; E E Zubrzycka-Gaarn; R G Worton; P N Ray
Journal: Am J Hum Genet Date: 1991-02 Impact factor: 11.025

10. Exploring the molecular basis for variability among patients with Becker muscular dystrophy: dystrophin gene and protein studies.

Authors: A H Beggs; E P Hoffman; J R Snyder; K Arahata; L Specht; F Shapiro; C Angelini; H Sugita; L M Kunkel
Journal: Am J Hum Genet Date: 1991-07 Impact factor: 11.025

8 in total

1. Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells.

Authors: A Fassati; D J Wells; P A Sgro Serpente; F S Walsh; S C Brown; P N Strong; G Dickson
Journal: J Clin Invest Date: 1997-08-01 Impact factor: 14.808

2. Delivery of AAV2/9-microdystrophin genes incorporating helix 1 of the coiled-coil motif in the C-terminal domain of dystrophin improves muscle pathology and restores the level of α1-syntrophin and α-dystrobrevin in skeletal muscles of mdx mice.

Authors: Taeyoung Koo; Alberto Malerba; Takis Athanasopoulos; Capucine Trollet; Luisa Boldrin; Arnaud Ferry; Linda Popplewell; Helen Foster; Keith Foster; George Dickson
Journal: Hum Gene Ther Date: 2011-05-25 Impact factor: 5.695

3. A novel point mutation (G-1 to T) in a 5' splice donor site of intron 13 of the dystrophin gene results in exon skipping and is responsible for Becker muscular dystrophy.

Authors: Y Hagiwara; H Nishio; Y Kitoh; Y Takeshima; N Narita; H Wada; M Yokoyama; H Nakamura; M Matsuo
Journal: Am J Hum Genet Date: 1994-01 Impact factor: 11.025

4. Exon skipping and translation in patients with frameshift deletions in the dystrophin gene.

Authors: T G Sherratt; T Vulliamy; V Dubowitz; C A Sewry; P N Strong
Journal: Am J Hum Genet Date: 1993-11 Impact factor: 11.025

5. Deletions in the 5' region of dystrophin and resulting phenotypes.

Authors: F Muntoni; P Gobbi; C Sewry; T Sherratt; J Taylor; S K Sandhu; S Abbs; R Roberts; S V Hodgson; M Bobrow
Journal: J Med Genet Date: 1994-11 Impact factor: 6.318

6. Assignment of laminin heavy chains using the lectin Ricinus communis agglutinin-1.

Authors: J D Wadsworth; A Okuno; P N Strong
Journal: Biochem J Date: 1993-10-15 Impact factor: 3.857

7. Massive idiosyncratic exon skipping corrects the nonsense mutation in dystrophic mouse muscle and produces functional revertant fibers by clonal expansion.

Authors: Q L Lu; G E Morris; S D Wilton; T Ly; O V Artem'yeva; P Strong; T A Partridge
Journal: J Cell Biol Date: 2000-03-06 Impact factor: 10.539

8. Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy.

Authors: Alberto Malerba; Jagjeet K Kang; Graham McClorey; Amer F Saleh; Linda Popplewell; Michael J Gait; Matthew Ja Wood; George Dickson
Journal: Mol Ther Nucleic Acids Date: 2012-12-18 Impact factor: 10.183

8 in total