[Insufficiency of nigrostriatal dopaminergic system as a disregulation mechanism of dopamine-dependent depression syndrome].

Considered here, is a role of insufficiency of central dopaminergic systems in the pathogenesis of depression. Experimental data have been obtained in a rat model of depression-like syndrome caused by administration of specific-for-dopamine-neurons neurotoxin 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine. Along with literature data, these results suggest a reduction of dopaminergic system activity in striatum, accompanied by the latter's hyperactivation, as a pathophysiological mechanism for development of certain depressive disorders.