Literature DB >> 12800172

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.

Jacob A Olsen1, David W Banner, Paul Seiler, Ulrike Obst Sander, Allan D'Arcy, Martine Stihle, Klaus Müller, François Diederich.   

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Year:  2003        PMID： 12800172     DOI： 10.1002/anie.200351268

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  23 in total

1.  Fluorine bonding enhances the energetics of protein-lipid binding in the gas phase.

Authors:  Lan Liu; Nobar Jalili; Alyson Baergen; Simon Ng; Justin Bailey; Ratmir Derda; John S Klassen
Journal:  J Am Soc Mass Spectrom       Date:  2014-05       Impact factor: 3.109

2.  From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators.

Authors:  Haibo Xie; Ka Yang; Gabrielle N Winston-McPherson; Donnie S Stapleton; Mark P Keller; Alan D Attie; Kerry A Smith; Weiping Tang
Journal:  Eur J Med Chem       Date:  2020-08-04       Impact factor: 6.514

3.  Entropy drives selective fluorine recognition in the fluoroacetyl-CoA thioesterase from Streptomyces cattleya.

Authors:  Amy M Weeks; Ningkun Wang; Jeffrey G Pelton; Michelle C Y Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-16       Impact factor: 11.205

4.  Intimate interactions with carbonyl groups: dipole-dipole or n→π*?

Authors:  Kimberli J Kamer; Amit Choudhary; Ronald T Raines
Journal:  J Org Chem       Date:  2012-12-10       Impact factor: 4.354

5.  Design, synthesis and SAR study of 3rd-generation taxoids bearing 3-CH3, 3-CF3O and 3-CHF2O groups at the C2-benzoate position.

Authors:  Changwei Wang; Xin Wang; Yi Sun; Adam K Taouil; Su Yan; Galina I Botchkina; Iwao Ojima
Journal:  Bioorg Chem       Date:  2019-12-20       Impact factor: 5.275

6.  Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for gamma-aminobutyric acid aminotransferase. Conformational probes for GABA binding.

Authors:  Michael D Clift; Haitao Ji; Gildas P Deniau; David O'Hagan; Richard B Silverman
Journal:  Biochemistry       Date:  2007-11-08       Impact factor: 3.162

Review 7.  A medicinal chemist's guide to molecular interactions.

Authors:  Caterina Bissantz; Bernd Kuhn; Martin Stahl
Journal:  J Med Chem       Date:  2010-07-22       Impact factor: 7.446

8.  Mechanistic insight into inhibition of two-component system signaling.

Authors:  Samson Francis; Kaelyn E Wilke; Douglas E Brown; Erin E Carlson
Journal:  Medchemcomm       Date:  2012-11-21       Impact factor: 3.597

9.  Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes.

Authors:  Douglas L Orsi; Justin T Douglas; Jacob P Sorrentino; Ryan A Altman
Journal:  J Org Chem       Date:  2020-08-05       Impact factor: 4.354

10.  Aromatic N versus aromatic F: bioisosterism discovered in RNA base pairing interactions leads to a novel class of universal base analogs.

Authors:  Alrun N Koller; Jelena Bozilovic; Joachim W Engels; Holger Gohlke
Journal:  Nucleic Acids Res       Date:  2010-01-15       Impact factor: 16.971
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