OBJECTIVE: To assess the diagnostic utility of anti-hsp70 antibody screening in sudden deafness. DESIGNS: era from 27 patients with sudden deafness and 100 healthy blood donors were analyzed by Western blotting (WB) for the presence of antibodies against 68 kD heat shock protein (anti-hsp70). RESULTS: 19% of the patient sera and 14% of the control sera turned out positive, which was not significantly different. CONCLUSIONS: The anti-hsp70 WB test lacks clinical utility for diagnostic screening in patients with sudden deafness.
OBJECTIVE: To assess the diagnostic utility of anti-hsp70 antibody screening in sudden deafness. DESIGNS: era from 27 patients with sudden deafness and 100 healthy blood donors were analyzed by Western blotting (WB) for the presence of antibodies against 68 kD heat shock protein (anti-hsp70). RESULTS: 19% of the patient sera and 14% of the control sera turned out positive, which was not significantly different. CONCLUSIONS: The anti-hsp70 WB test lacks clinical utility for diagnostic screening in patients with sudden deafness.
Authors: Pavan K Kommareddi; Thankam S Nair; Mounica Vallurupalli; Steven A Telian; H Alexander Arts; Hussam K El-Kashlan; Robert T Sataloff; Thomas E Carey Journal: Laryngoscope Date: 2009-05 Impact factor: 3.325