Literature DB >> 12799028

Microarray analysis identifies interferon beta-regulated genes in multiple sclerosis.

Fumiko Koike1, Jun-ichi Satoh, Sachiko Miyake, Toshiyuki Yamamoto, Mitsuru Kawai, Seiji Kikuchi, Kyouichi Nomura, Kazumasa Yokoyama, Kohei Ota, Takashi Kanda, Toshiyuki Fukazawa, Takashi Yamamura.   

Abstract

The molecular mechanisms for the interferon beta (IFNbeta) treatment of multiple sclerosis (MS) remain to be characterized. Using cDNA microarray technology, we have compared the gene expression profile of T and non-T cells derived from relapsing-remitting MS before and after treatment with IFNbeta-1b. IFNbeta treatment significantly altered expression of 21 genes out of 1263 at 3 and 6 months after treatment. These genes included nine with IFN-responsive promoter elements. Whereas there was no change in Th1 or Th2 marker genes, some of the changes were unexpected but coincided with the beneficial effect of IFNbeta in MS.

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Year:  2003        PMID： 12799028     DOI： 10.1016/s0165-5728(03)00155-3

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  17 in total

Review 1.  The genetics of multiple sclerosis: an up-to-date review.

Authors:  Pierre-Antoine Gourraud; Hanne F Harbo; Stephen L Hauser; Sergio E Baranzini
Journal:  Immunol Rev       Date:  2012-07       Impact factor: 12.988

2.  Gene expression profile following stable expression of the cellular prion protein.

Authors:  Jun-ichi Satoh; Takashi Yamamura
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Review 3.  Genomics and proteomics: role in the management of multiple sclerosis.

Authors:  Ludwig Kappos; Lutz Achtnichts; Frank Dahlke; Jens Kuhle; Y Naegelin; Rupert Sandbrink; Raija L P Lindberg
Journal:  J Neurol       Date:  2005-09       Impact factor: 4.849

Review 4.  Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs.

Authors:  Adriana Albini; Stefano Indraccolo; Douglas M Noonan; Ulrich Pfeffer
Journal:  Clin Exp Metastasis       Date:  2010-04-10       Impact factor: 5.150

5.  Multiplexed Gene Expression as a Characterization of Bioactivity for Interferon Beta (IFN-β) Biosimilar Candidates: Impact of Innate Immune Response Modulating Impurities (IIRMIs).

Authors:  Eduardo F Mufarrege; Lydia A Haile; Marina Etcheverrigaray; Daniela I Verthelyi
Journal:  AAPS J       Date:  2019-02-08       Impact factor: 4.009

Review 6.  A genomic approach to human autoimmune diseases.

Authors:  Virginia Pascual; Damien Chaussabel; Jacques Banchereau
Journal:  Annu Rev Immunol       Date:  2010       Impact factor: 28.527

Review 7.  The immunopathophysiology of multiple sclerosis.

Authors:  Gregory F Wu; Enrique Alvarez
Journal:  Neurol Clin       Date:  2011-05       Impact factor: 3.806

8.  Gene expression studies in multiple sclerosis.

Authors:  Lotti Tajouri; Francesca Fernandez; Lyn R Griffiths
Journal:  Curr Genomics       Date:  2007-05       Impact factor: 2.236

9.  Comparative Neuroregenerative Effects of C-Phycocyanin and IFN-Beta in a Model of Multiple Sclerosis in Mice.

Authors:  Giselle Pentón-Rol; Nielsen Lagumersindez-Denis; Luca Muzio; Alessandra Bergami; Roberto Furlan; Julio R Fernández-Massó; Marcelo Nazabal-Galvez; Alexey Llópiz-Arzuaga; Tania Herrera-Rolo; Tania Veliz-Rodriguez; Nadia Polentarutti; Javier Marín-Prida; Ivette Raíces-Cruz; Carmen Valenzuela-Silva; Mauro Martins Teixeira; Eduardo Pentón-Arias
Journal:  J Neuroimmune Pharmacol       Date:  2015-11-10       Impact factor: 4.147

Review 10.  Monitoring of multiple sclerosis immunotherapy: from single candidates to biomarker networks.

Authors:  Robert H Goertsches; Michael Hecker; Uwe K Zettl
Journal:  J Neurol       Date:  2008-12       Impact factor: 4.849
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