Literature DB >> 12799014

Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis.

Maria Pagany1, Maja Jagodic, Carole Bourquin, Tomas Olsson, Christopher Linington.   

Abstract

Myelin oligodendrocyte glycoprotein (MOG) is encoded within the RT1.M region of the rat MHC a susceptibility locus for MOG-induced experimental autoimmune encephalomyelitis (EAE). We report that the enhanced susceptibility of Brown Norway (BN) rats to MOG-EAE is associated with higher expression of MOG mRNA and protein in the nervous system than in the less susceptible Lewis (LEW) strain. MOG mRNA was also detected in the immune system, but there was no correlation with disease susceptibility. These results suggest that differences in the expression of MOG in the target organ, rather than in the immune system may influence susceptibility to MOG-EAE.

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Year:  2003        PMID： 12799014     DOI： 10.1016/s0165-5728(03)00124-3

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  9 in total

1.  Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more.

Authors:  Marie Cathrin Mayer; Edgar Meinl
Journal:  Ther Adv Neurol Disord       Date:  2012-05       Impact factor: 6.570

2.  Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus.

Authors:  Haolong Cong; Yue Jiang; Po Tien
Journal:  J Virol       Date:  2011-08-31       Impact factor: 5.103

3.  2-photon imaging of phagocyte-mediated T cell activation in the CNS.

Authors:  Marija Pesic; Ingo Bartholomäus; Nikolaos I Kyratsous; Vigo Heissmeyer; Hartmut Wekerle; Naoto Kawakami
Journal:  J Clin Invest       Date:  2013-02-01       Impact factor: 14.808

4.  Extensive infiltration of neutrophils in the acute phase of experimental autoimmune encephalomyelitis in C57BL/6 mice.

Authors:  Fenglan Wu; Wei Cao; Yiqing Yang; Ailian Liu
Journal:  Histochem Cell Biol       Date:  2010-03       Impact factor: 4.304

5.  The genomic sequence and comparative analysis of the rat major histocompatibility complex.

Authors:  Peter Hurt; Lutz Walter; Ralf Sudbrak; Sven Klages; Ines Müller; Takashi Shiina; Hidetoshi Inoko; Hans Lehrach; Eberhard Günther; Richard Reinhardt; Heinz Himmelbauer
Journal:  Genome Res       Date:  2004-04       Impact factor: 9.043

6.  Humoral response in experimental autoimmune encephalomyelitis targets neural precursor cells in the central nervous system of naive rodents.

Authors:  Evangelia Kesidou; Olga Touloumi; Roza Lagoudaki; Evangelia Nousiopoulou; Paschalis Theotokis; Kyriaki-Nepheli Poulatsidou; Marina Boziki; Evangelia Kofidou; Nickoleta Delivanoglou; Fani Minti; Georgios Hadjigeorgiou; Nikolaos Grigoriadis; Constantina Simeonidou
Journal:  J Neuroinflammation       Date:  2017-11-21       Impact factor: 8.322

7.  Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells.

Authors:  Bernadette Pöllinger; Gurumoorthy Krishnamoorthy; Kerstin Berer; Hans Lassmann; Michael R Bösl; Robert Dunn; Helena S Domingues; Andreas Holz; Florian C Kurschus; Hartmut Wekerle
Journal:  J Exp Med       Date:  2009-06-01       Impact factor: 14.307

8.  Splice variation in the cytoplasmic domains of myelin oligodendrocyte glycoprotein affects its cellular localisation and transport.

Authors:  Louise H Boyle; James A Traherne; Gemma Plotnek; Rosemary Ward; John Trowsdale
Journal:  J Neurochem       Date:  2007-06-15       Impact factor: 5.372

9.  Antibodies to the RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein A1 Colocalize to Stress Granules Resulting in Altered RNA and Protein Levels in a Model of Neurodegeneration in Multiple Sclerosis.

Authors:  Joshua N Douglas; Lidia A Gardner; Hannah E Salapa; Michael C Levin
Journal:  J Clin Cell Immunol       Date:  2016-03-22
  9 in total

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