OBJECTIVE: To develop a model of pathogenesis by which Chlamydia trachomatis progresses from acute to chronic infection, and finally serious disease (salpingitis, tubal occlusion). DESIGN: Review of current literature located through web-based Medline searches using key words: Chlamydia trachomatis, immunology, cytokines, heat shock protein, infertility. RESULT(S): Cell-mediated immune mechanisms appear to be critical in determining whether acute infection is resolved or progresses into chronicity with pathological outcome. What determines the particular immune pathway depends on a range of determinants-HLA subtype and human genetics, cytokine profile, infectious load, route of infection, and endocrinology. A clearer picture of the natural history of chlamydial pathology may assist in providing better predictors of those women who may go on to develop significant sequelae after infection. CONCLUSION(S): Predicting those who may develop serious disease, including infertility, may contribute to improved management of such persons during earlier stages of infection and assist in prevention.
OBJECTIVE: To develop a model of pathogenesis by which Chlamydia trachomatis progresses from acute to chronic infection, and finally serious disease (salpingitis, tubal occlusion). DESIGN: Review of current literature located through web-based Medline searches using key words: Chlamydia trachomatis, immunology, cytokines, heat shock protein, infertility. RESULT(S): Cell-mediated immune mechanisms appear to be critical in determining whether acute infection is resolved or progresses into chronicity with pathological outcome. What determines the particular immune pathway depends on a range of determinants-HLA subtype and human genetics, cytokine profile, infectious load, route of infection, and endocrinology. A clearer picture of the natural history of chlamydial pathology may assist in providing better predictors of those women who may go on to develop significant sequelae after infection. CONCLUSION(S): Predicting those who may develop serious disease, including infertility, may contribute to improved management of such persons during earlier stages of infection and assist in prevention.
Authors: Weidang Li; Ashlesh K Murthy; M Neal Guentzel; James P Chambers; Thomas G Forsthuber; J Seshu; Guangming Zhong; Bernard P Arulanandam Journal: Infect Immun Date: 2010-07-06 Impact factor: 3.441
Authors: Joseph U Igietseme; Yusuf Omosun; Tamas Nagy; Olga Stuchlik; Matthew S Reed; Qing He; James Partin; Kahaliah Joseph; Debra Ellerson; Zenas George; Jason Goldstein; Francis O Eko; Claudiu Bandea; Jan Pohl; Carolyn M Black Journal: Infect Immun Date: 2017-12-19 Impact factor: 3.441
Authors: Ashlesh K Murthy; Weidang Li; Bharat K R Chaganty; Sangamithra Kamalakaran; M Neal Guentzel; J Seshu; Thomas G Forsthuber; Guangming Zhong; Bernard P Arulanandam Journal: Infect Immun Date: 2011-05-02 Impact factor: 3.441
Authors: Juan Pablo Mackern-Oberti; Mariana Maccioni; Cecilia Cuffini; Gerardo Gatti; Virginia E Rivero Journal: Infect Immun Date: 2006-09-05 Impact factor: 3.441
Authors: Ashlesh K Murthy; Bharat K R Chaganty; Weidang Li; M Neal Guentzel; James P Chambers; J Seshu; Guangming Zhong; Bernard P Arulanandam Journal: FEMS Immunol Med Microbiol Date: 2009-03
Authors: Manoj Gambhir; Maria-Gloria Basáñez; Matthew J Burton; Anthony W Solomon; Robin L Bailey; Martin J Holland; Isobel M Blake; Christl A Donnelly; Ibrahim Jabr; David C Mabey; Nicholas C Grassly Journal: PLoS Negl Trop Dis Date: 2009-06-16