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Literature DB >> 1279866

An enzymatic mechanism for potassium channel stimulation through pertussis-toxin-sensitive G proteins.

Abstract

Many neurotransmitters inhibit secretion from electrically excitable cells by activating pertussis-toxin-sensitive G proteins that modulate voltage-gated ion channels. Recent electrophysiological studies of metabolically intact cells from mammalian and molluscan neuroendocrine systems have implicated protein phosphatases in this process. In this article David Armstrong and Richard White review these studies and suggest a biochemical pathway that might link one of the G proteins to protein phosphatase activity.

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Year: 1992 PMID： 1279866 DOI： 10.1016/0166-2236(92)90192-b

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

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Cited

12 in total

1. Conditional protein phosphorylation regulates BK channel activity in rat cerebellar Purkinje neurons.

Authors: Hélène A Widmer; Iain C M Rowe; Michael J Shipston
Journal: J Physiol Date: 2003-10-15 Impact factor: 5.182

2. Reciprocal modulation of phospholipase Cbeta isoforms: adaptation to chronic morphine.

Authors: Sumita Chakrabarti; Nai-Jiang Liu; Alan R Gintzler
Journal: Proc Natl Acad Sci U S A Date: 2003-11-03 Impact factor: 11.205

3. Rac GTPase signaling through the PP5 protein phosphatase.

Authors: Saverio Gentile; Thomas Darden; Christian Erxleben; Charles Romeo; Angela Russo; Negin Martin; Sandra Rossie; David L Armstrong
Journal: Proc Natl Acad Sci U S A Date: 2006-03-20 Impact factor: 11.205

4. Gramicidin-perforated patch recording: GABA response in mammalian neurones with intact intracellular chloride.

Authors: S Ebihara; K Shirato; N Harata; N Akaike
Journal: J Physiol Date: 1995-04-01 Impact factor: 5.182

5. Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

Authors: N Qin; D Platano; R Olcese; E Stefani; L Birnbaumer
Journal: Proc Natl Acad Sci U S A Date: 1997-08-05 Impact factor: 11.205

An enzymatic mechanism for potassium channel stimulation through pertussis-toxin-sensitive G proteins.

1. Conditional protein phosphorylation regulates BK channel activity in rat cerebellar Purkinje neurons.

2. Reciprocal modulation of phospholipase Cbeta isoforms: adaptation to chronic morphine.

3. Rac GTPase signaling through the PP5 protein phosphatase.

4. Gramicidin-perforated patch recording: GABA response in mammalian neurones with intact intracellular chloride.

5. Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

6. Modulation of the serotonin-activated K+ channel by G protein subunits and nucleotides in rat hippocampal neurons.

7. Activation of glutamate receptors in response to membrane depolarization of hair cells isolated from chick cochlea.

8. Polyamines block Ca(2+)-activated K+ channels in pituitary tumor cells (GH3).

9. Biphasic and differential modulation of Ca2+ entry by ATP and UTP in promyelocytic leukaemia HL60 cells.

10. Enhancement by muscarinic agonists of a high voltage-activated Ca2+ current via phosphorylation in a snail neuron.