Literature DB >> 12798650

Immunization with recombinant paraflagellar rod protein induces protective immunity against Trypanosoma cruzi infection.

Keith A Luhrs1, David L Fouts, Jerry E Manning.   

Abstract

In the present study, we have produced recombinant paraflagellar rod proteins (PFR) and report their use for successful vaccination of mice against Trypanosoma cruzi. This protection is associated with a highly polarized type 1 cytokine production profile. Additionally, we have analyzed the gene sequence encoding PFR-2 to determine the degree of conservation among seven highly diverse strains of T. cruzi, and found it to be highly conserved. The results presented here indicate that the PFR antigens are highly conserved, and immunization with rPFR-1, PFR-2, or an equimolar mix of the PFR-1, -2, and -3 proteins provides protective immunity against Trypanosoma cruzi.

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Year:  2003        PMID： 12798650     DOI： 10.1016/s0264-410x(03)00108-7

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  16 in total

Review 1.  An overview on kinetoplastid paraflagellar rod.

Authors:  B R Maharana; A K Tewari; Veer Singh
Journal:  J Parasit Dis       Date:  2014-02-07

2.  CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2.

Authors:  Adriano F S Araújo; Bruna C G de Alencar; José Ronnie C Vasconcelos; Meire I Hiyane; Cláudio R F Marinho; Marcus L O Penido; Silvia B Boscardin; Daniel F Hoft; Ricardo T Gazzinelli; Mauricio M Rodrigues
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

3.  Anatomical route of invasion and protective mucosal immunity in Trypanosoma cruzi conjunctival infection.

Authors:  O K Giddings; C S Eickhoff; T J Smith; L A Bryant; D F Hoft
Journal:  Infect Immun       Date:  2006-10       Impact factor: 3.441

4.  The Trypanosoma cruzi flagellum is discarded via asymmetric cell division following invasion and provides early targets for protective CD8⁺ T cells.

Authors:  Samarchith P Kurup; Rick L Tarleton
Journal:  Cell Host Microbe       Date:  2014-10-08       Impact factor: 21.023

5.  Cloning and expression analysis of two novel paraflagellar rod domain genes found in Trypanosoma cruzi.

Authors:  April K Clark; Gennadiy Kovtunovych; Sachin Kandlikar; Shailesh Lal; Gabrielle A Stryker
Journal:  Parasitol Res       Date:  2005-05-26       Impact factor: 2.289

6.  Challenge of chronically infected mice with homologous trypanosoma cruzi parasites enhances the immune response but does not modify cardiopathy: implications for the design of a therapeutic vaccine.

Authors:  Christian Emerson Rosas-Jorquera; Luiz Roberto Sardinha; Fernando Delgado Pretel; André Luis Bombeiro; Maria Regina D'Império Lima; José Maria Alvarez
Journal:  Clin Vaccine Immunol       Date:  2012-12-19

Review 7.  The paraflagellar rod of kinetoplastid parasites: from structure to components and function.

Authors:  Neil Portman; Keith Gull
Journal:  Int J Parasitol       Date:  2009-10-30       Impact factor: 3.981

8.  Immunolocalization and challenge studies using a recombinant Vibrio cholerae ghost expressing Trypanosoma brucei Ca(2+) ATPase (TBCA2) antigen.

Authors:  Kiantra Ramey; Francis O Eko; Winston E Thompson; Henry Armah; Joseph U Igietseme; Jonathan K Stiles
Journal:  Am J Trop Med Hyg       Date:  2009-09       Impact factor: 2.345

9.  Novel protective antigens expressed by Trypanosoma cruzi amastigotes provide immunity to mice highly susceptible to Chagas' disease.

Authors:  Eduardo L V Silveira; Carla Claser; Filipe A B Haolla; Luiz G Zanella; Mauricio M Rodrigues
Journal:  Clin Vaccine Immunol       Date:  2008-06-25

10.  Parasite-induced chronic inflammation is not exacerbated by immunotherapy before or during Trypanosoma cruzi Infection.

Authors:  Malcolm S Duthie; Maria Kahn; Arsen Zakayan; Maria White; Stuart J Kahn
Journal:  Clin Vaccine Immunol       Date:  2007-05-30
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