Literature DB >> 12798374

Improved synthesis of anti-[18F]FACBC: improved preparation of labeling precursor and automated radiosynthesis.

Jonathan McConathy1, Ronald J Voll, Weiping Yu, Ronald J Crowe, Mark M Goodman.   

Abstract

The non-natural amino acid anti-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid (FACBC) has shown promise for tumor imaging with positron emission tomography. An improved synthesis of the precursor of anti-[18F]FACBC has been devised which demonstrates high stereoselectivity and suitability for large-scale preparations. An automated radiosynthesis has been developed which provides anti-[18F]FACBC in 24% decay-corrected yield. Additionally, the major non-radioactive species present in doses of anti-[18F]FACBC has been identified as anti-1-amino-3-hydroxycyclobutane-1-carboxylic acid. Together, these results are important steps towards the routine production of anti-[18F]FACBC for human use.

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Year:  2003        PMID： 12798374     DOI： 10.1016/s0969-8043(03)00029-0

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  33 in total

1.  Preclinical characterization of 18F-D-FPHCys, a new amino acid-based PET tracer.

Authors:  Delphine Denoyer; Laura Kirby; Kelly Waldeck; Peter Roselt; Oliver C Neels; Thomas Bourdier; Rachael Shepherd; Andrew Katsifis; Rodney J Hicks
Journal:  Eur J Nucl Med Mol Imaging       Date:  2011-12-13       Impact factor: 9.236

2.  Detection of recurrent prostate carcinoma with anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid PET/CT and 111In-capromab pendetide SPECT/CT.

Authors:  David M Schuster; Bital Savir-Baruch; Peter T Nieh; Viraj A Master; Raghuveer K Halkar; Peter J Rossi; Melinda M Lewis; Jonathon A Nye; Weiping Yu; F DuBois Bowman; Mark M Goodman
Journal:  Radiology       Date:  2011-04-14       Impact factor: 11.105

Review 3.  Anatomic and Molecular Imaging in Prostate Cancer.

Authors:  Eric T Miller; Amirali Salmasi; Robert E Reiter
Journal:  Cold Spring Harb Perspect Med       Date:  2018-03-01       Impact factor: 6.915

4.  Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain tumors.

Authors:  Weiping Yu; Jonathan McConathy; Larry Williams; Vernon M Camp; Eugene J Malveaux; Zhaobin Zhang; Jeffrey J Olson; Mark M Goodman
Journal:  J Med Chem       Date:  2010-01-28       Impact factor: 7.446

5.  Impact of 18F-Fluciclovine PET on Target Volume Definition for Postprostatectomy Salvage Radiotherapy: Initial Findings from a Randomized Trial.

Authors:  Ashesh B Jani; Eduard Schreibmann; Peter J Rossi; Joseph Shelton; Karen Godette; Peter Nieh; Viraj A Master; Omer Kucuk; Mark Goodman; Raghuveer Halkar; Sherrie Cooper; Zhengjia Chen; David M Schuster
Journal:  J Nucl Med       Date:  2016-09-08       Impact factor: 10.057

6.  Change in Salvage Radiotherapy Management Based on Guidance With FACBC (Fluciclovine) PET/CT in Postprostatectomy Recurrent Prostate Cancer.

Authors:  Oladunni O Akin-Akintayo; Ashesh B Jani; Oluwaseun Odewole; Funmilayo I Tade; Peter T Nieh; Viraj A Master; Leah M Bellamy; Raghuveer K Halkar; Chao Zhang; Zhengjia Chen; Mark M Goodman; David M Schuster
Journal:  Clin Nucl Med       Date:  2017-01       Impact factor: 7.794

7.  Initial experience with the radiotracer anti-1-amino-3-[18F]Fluorocyclobutane-1-carboxylic acid (anti-[ 18F]FACBC) with PET in renal carcinoma.

Authors:  David M Schuster; Jonathon A Nye; Peter T Nieh; John R Votaw; Raghuveer K Halkar; Muta M Issa; Weiping Yu; Julio Sepulveda; Wanzhen Zeng; Andrew Young; Mark M Goodman
Journal:  Mol Imaging Biol       Date:  2009-05-16       Impact factor: 3.488

8.  The clinical safety, biodistribution and internal radiation dosimetry of [¹⁸F]fluciclovine in healthy adult volunteers.

Authors:  Brian J McParland; Anders Wall; Silvia Johansson; Jens Sørensen
Journal:  Eur J Nucl Med Mol Imaging       Date:  2013-04-24       Impact factor: 9.236

Review 9.  Radiopharmaceuticals in preclinical and clinical development for monitoring of therapy with PET.

Authors:  Mark P S Dunphy; Jason S Lewis
Journal:  J Nucl Med       Date:  2009-04-20       Impact factor: 10.057

10.  Pilot study of the utility of the synthetic PET amino-acid radiotracer anti-1-amino-3-[(18)F]fluorocyclobutane-1-carboxylic acid for the noninvasive imaging of pulmonary lesions.

Authors:  Rianot Amzat; Pooneh Taleghani; Daniel L Miller; Jonathan J Beitler; Leah M Bellamy; Jonathon A Nye; Weiping Yu; Bital Savir-Baruch; Adeboye O Osunkoya; Zhengjia Chen; William F Auffermann; Mark M Goodman; David M Schuster
Journal:  Mol Imaging Biol       Date:  2013-10       Impact factor: 3.488
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