Literature DB >> 12798357

The detection of 20S-hydroxycholesterol in extracts of rat brains and human placenta by a gas chromatograph/mass spectrometry technique.

Ying Yong Lin1, Margaret Welch, Seymour Lieberman.   

Abstract

The presence of 20(S)-hydroxycholesterol in rat brains and human placenta has been established using the gas chromatography/mass spectrometry (GC/MS) select ion monitoring (SIM) technique. Identification was ensured by three criteria: the specific retention time when the compound emerges from the gas chromatogram and the two m/z ions (201 and 461amu) which are characteristic of its mass spectrum. The possible role of 20(S)-hydroxycholesterol in steroid hormone biosynthesis and in other biological processes is discussed.

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Year:  2003        PMID： 12798357     DOI： 10.1016/s0960-0760(03)00137-7

Source DB:  PubMed          Journal:  J Steroid Biochem Mol Biol        ISSN： 0960-0760            Impact factor:   4.292


  12 in total

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5.  Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols.

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6.  Oxysterols are allosteric activators of the oncoprotein Smoothened.

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8.  Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism.

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Review 9.  Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites.

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10.  Analysis of oxysterols by electrospray tandem mass spectrometry.

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