Literature DB >> 12798337

Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents.

Xiangshu Fei1, Qi Huang Zheng, Xuan Liu, Ji Quan Wang, Hui Bin Sun, Bruce H Mock, K Lee Stone, Kathy D Miller, George W Sledge, Gary D Hutchins.   

Abstract

Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2',3',4'-methoxybiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1a-c), (S)-3-methyl-2-(2',3',4'-fluorobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1d-f), and (S)-3-methyl-2-(4'-nitrobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents.

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Year:  2003        PMID： 12798337     DOI： 10.1016/s0960-894x(03)00382-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Molecular Imaging of Proteases in Cancer.

Authors:  Yunan Yang; Hao Hong; Yin Zhang; Weibo Cai
Journal:  Cancer Growth Metastasis       Date:  2009-08-17

Review 2.  Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.

Authors:  Jonathan P Celli; Bryan Q Spring; Imran Rizvi; Conor L Evans; Kimberley S Samkoe; Sarika Verma; Brian W Pogue; Tayyaba Hasan
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

Review 3.  Positron emission tomography tracers for imaging angiogenesis.

Authors:  Roland Haubner; Ambros J Beer; Hui Wang; Xiaoyuan Chen
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-08       Impact factor: 9.236

4.  Stroma targeting nuclear imaging and radiopharmaceuticals.

Authors:  Dinesh Shetty; Jae-Min Jeong; Hyunsuk Shim
Journal:  Int J Mol Imaging       Date:  2012-05-21

Review 5.  Molecular Imaging Probes Based on Matrix Metalloproteinase Inhibitors (MMPIs).

Authors:  Loganathan Rangasamy; Bruno Di Geronimo; Irene Ortín; Claire Coderch; José María Zapico; Ana Ramos; Beatriz de Pascual-Teresa
Journal:  Molecules       Date:  2019-08-16       Impact factor: 4.411

Review 6.  Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review.

Authors:  Chuang Zhao; K P Rakesh; L Ravidar; Wan-Yin Fang; Hua-Li Qin
Journal:  Eur J Med Chem       Date:  2018-11-22       Impact factor: 6.514
  6 in total

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