Literature DB >> 12798313

Novel inhibitors of procollagen C-terminal proteinase. Part 1: diamino Acid hydroxamates.

N G J Delaet1, L A Robinson, D M Wilson, R W Sullivan, E K Bradley, S M Dankwardt, R L Martin, H E Van Wart, K A M Walker.   

Abstract

The parallel synthesis of novel inhibitors of procollagen C-terminal proteinase is described. The synthetic strategy allowed for the facile synthesis of a large number of side-chain diversified diamino acid hydroxamates, of which the D-diaminopropionic acid derivatives were shown to be single digit nanomolar PCP inhibitors.

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Year:  2003        PMID: 12798313     DOI: 10.1016/s0960-894x(03)00404-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  3-Hy-droxy-2-(4-meth-oxy-benzene-sulfonamido)-butanoic acid.

Authors:  Suman Sinha; Hasnah Osman; Habibah A Wahab; Madhukar Hemamalini; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-11-12
  1 in total

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