Literature DB >> 12797705

Variants of the human NRAMP1 gene and susceptibility to tuberculosis in Morocco.

J El Baghdadi1, N Remus, A Benslimane, H El Annaz, M Chentoufi, L Abel, E Schurr.   

Abstract

It has been well established that the host genetic background is an important modulator of tuberculosis susceptibility. The NRAMP1 (alias SLC11A1) gene has been associated with tuberculosis susceptibility in several ethnic groups. Here we studied the association and linkage of NRAMP1 with tuberculosis in 116 nuclear families, comprising 211 affected offspring, from Casablanca, Morocco. All enrolled tuberculosis cases were culture-positive. No evidence was found of linkage or association of NRAMP1 with tuberculosis. These findings suggest heterogeneity in the genetic control of tuberculosis susceptibility.

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Year:  2003        PMID： 12797705

Source DB:  PubMed          Journal:  Int J Tuberc Lung Dis        ISSN： 1027-3719            Impact factor:   2.373


  18 in total

Review 1.  Innate immune gene polymorphisms in tuberculosis.

Authors:  Abul K Azad; Wolfgang Sadee; Larry S Schlesinger
Journal:  Infect Immun       Date:  2012-07-23       Impact factor: 3.441

2.  Variants of the natural resistance-associated macrophage protein 1 gene (NRAMP1) are associated with severe forms of pulmonary tuberculosis.

Authors:  Wenghong Zhang; Linyun Shao; Xinhua Weng; Zhongyi Hu; Anjia Jin; Shu Chen; Maoyin Pang; Zheng W Chen
Journal:  Clin Infect Dis       Date:  2005-03-23       Impact factor: 9.079

Review 3.  The emergence of Beijing family genotypes of Mycobacterium tuberculosis and low-level protection by bacille Calmette-Guérin (BCG) vaccines: is there a link?

Authors:  F Abebe; G Bjune
Journal:  Clin Exp Immunol       Date:  2006-09       Impact factor: 4.330

Review 4.  Tuberculosis as a complex trait: impact of genetic epidemiological study design.

Authors:  Catherine M Stein; Allison R Baker
Journal:  Mamm Genome       Date:  2010-11-23       Impact factor: 2.957

5.  Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease.

Authors:  Suneil Malik; Laurent Abel; Heather Tooker; Audrey Poon; Leah Simkin; Manon Girard; Gerald J Adams; Jeffrey R Starke; Kimberly C Smith; Edward A Graviss; James M Musser; Erwin Schurr
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-15       Impact factor: 11.205

6.  Correlation of virulence, lung pathology, bacterial load and delayed type hypersensitivity responses after infection with different Mycobacterium tuberculosis genotypes in a BALB/c mouse model.

Authors:  J Dormans; M Burger; D Aguilar; R Hernandez-Pando; K Kremer; P Roholl; S M Arend; D van Soolingen
Journal:  Clin Exp Immunol       Date:  2004-09       Impact factor: 4.330

Review 7.  Human genetics of common mycobacterial infections.

Authors:  Natascha Remus; Alexandre Alcaïs; Laurent Abel
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

8.  Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians.

Authors:  D R Velez; W F Hulme; J L Myers; M E Stryjewski; E Abbate; R Estevan; S G Patillo; J R Gilbert; C D Hamilton; W K Scott
Journal:  Int J Tuberc Lung Dis       Date:  2009-09       Impact factor: 2.373

9.  Polymorphisms of the NRAMP1 gene: distribution and susceptibility to the development of pulmonary tuberculosis in the Greek population.

Authors:  Marios K Stagas; Georgios S Papaetis; Dora Orphanidou; Charalambos Kostopoulos; Stavroula Syriou; Martin Reczko; Nikolaos Drakoulis
Journal:  Med Sci Monit       Date:  2011-01

Review 10.  Genetic epidemiology of tuberculosis susceptibility: impact of study design.

Authors:  Catherine M Stein
Journal:  PLoS Pathog       Date:  2011-01-20       Impact factor: 6.823
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