| Literature DB >> 12796538 |
P Leuraud1, L Aguirre-Cruz, K Hoang-Xuan, E Crinière, M-L Tanguy, J-L Golmard, M Kujas, J-Y Delattre, M Sanson.
Abstract
An inhibitor of telomerase activity maps to chromosome 10p15.1. A series of 51 high-grade gliomas was analyzed for loss of heterozygosity (LOH) on chromosome 10 and for telomerase activity. In univariate analysis, LOH10p (59%) and LOH10q (61%) were associated with telomerase activity (55%; p < 0.0001 and p = 0.0006). In multivariate analysis, only LOH10p remained statistically related to telomerase activity, suggesting that the telomerase repressor gene located on 10p15.1 is inactivated in high-grade gliomas.Entities:
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Year: 2003 PMID： 12796538 DOI： 10.1212/01.wnl.0000065894.89082.5e
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910