OBJECTIVE: To design a spirometry-based algorithm to predict pulmonary restrictive impairment and reduce the number of patients undergoing unnecessary lung volume testing. DESIGN: Two prospective studies of 259 consecutive patients and 265 consecutive patients used to derive and validate the algorithm, respectively. SETTING: A pulmonary function laboratory of a tertiary care hospital. PATIENTS: Consecutive adults referred to the laboratory for lung volume measurements and spirometry. MEASUREMENTS: The sensitivity of the algorithm for predicting pulmonary restriction and the cost savings associated with its use. RESULTS: Total lung capacity correlated strongly with FVC (r = 0.66) and showed an inverse correlation with the FEV(1)/FVC ratio (r = - 0.41). According to the algorithm, only patients with an FVC < 85% of predicted and an FEV(1)/FVC ratio >or= 55% required lung volume measurements following spirometry. The algorithm had a high sensitivity for predicting restriction and a high negative predictive value (NPV) for excluding restriction (sensitivity, 96%; NPV, 98%). The diagnostic properties of the algorithm were reproducible in the validation study. Application of the algorithm would eliminate the need for lung volume testing in 48 to 49% of patients referred to the pulmonary function test (PFT) laboratory, reducing costs by 33%. CONCLUSIONS: A spirometry-based algorithm accurately excludes pulmonary restriction and reduces unnecessary lung volume testing in the PFT laboratory almost in half.
OBJECTIVE: To design a spirometry-based algorithm to predict pulmonary restrictive impairment and reduce the number of patients undergoing unnecessary lung volume testing. DESIGN: Two prospective studies of 259 consecutive patients and 265 consecutive patients used to derive and validate the algorithm, respectively. SETTING: A pulmonary function laboratory of a tertiary care hospital. PATIENTS: Consecutive adults referred to the laboratory for lung volume measurements and spirometry. MEASUREMENTS: The sensitivity of the algorithm for predicting pulmonary restriction and the cost savings associated with its use. RESULTS: Total lung capacity correlated strongly with FVC (r = 0.66) and showed an inverse correlation with the FEV(1)/FVC ratio (r = - 0.41). According to the algorithm, only patients with an FVC < 85% of predicted and an FEV(1)/FVC ratio >or= 55% required lung volume measurements following spirometry. The algorithm had a high sensitivity for predicting restriction and a high negative predictive value (NPV) for excluding restriction (sensitivity, 96%; NPV, 98%). The diagnostic properties of the algorithm were reproducible in the validation study. Application of the algorithm would eliminate the need for lung volume testing in 48 to 49% of patients referred to the pulmonary function test (PFT) laboratory, reducing costs by 33%. CONCLUSIONS: A spirometry-based algorithm accurately excludes pulmonary restriction and reduces unnecessary lung volume testing in the PFT laboratory almost in half.
Authors: Carlos A Vaz Fragoso; Thomas M Gill; Gail McAvay; Henry Klar Yaggi; Peter H Van Ness; John Concato Journal: J Investig Med Date: 2011-10 Impact factor: 2.895
Authors: David J Lederer; Paul L Enright; Steven M Kawut; Eric A Hoffman; Gary Hunninghake; Edwin J R van Beek; John H M Austin; Rui Jiang; Gina S Lovasi; R Graham Barr Journal: Am J Respir Crit Care Med Date: 2009-06-19 Impact factor: 21.405
Authors: Carlos A Vaz Fragoso; Hilary C Cain; Richard Casaburi; Patty J Lee; Lynne Iannone; Linda S Leo-Summers; Peter H Van Ness Journal: Respir Care Date: 2017-07-11 Impact factor: 2.258
Authors: Carlos A Vaz Fragoso; Thomas M Gill; Gail McAvay; Peter H Van Ness; H Klar Yaggi; John Concato Journal: Respir Care Date: 2011-05-20 Impact factor: 2.258