BACKGROUND: One approach for prevention of cutaneous leishmaniasis (CL) is the creation of a barrier between the insect vector (phlebotoms) and the host. Many but not all researchers claim that permethrin-impregnated uniforms are effective for prevention of CL. We determined the efficacy of permethrin-impregnated uniforms for prevention of CL in Iranian soldiers. METHODS:A total of 324 soldiers were randomized to two equal groups, of which 272 soldiers completed the study. In group A, 134 soldiers were issued permethrin-impregnated uniforms. In group B, 138 soldiers were issued uniforms washed in water. The soldiers wore uniforms day and night for 3 months, and were observed for an additional period of 6 months. All the soldiers remained in the leishmania-endemic area of Isfahan during the 3 months. RESULTS: Nine (6.5%) of 138 soldiers wearing control uniforms and six (4.4%) of 134 soldiers wearing permathrin-impregnated uniforms acquired CL. The difference between two groups was not statistically significant (P < 0.05). CONCLUSION:Permethrin-impregnated uniforms are not effective for the prevention of CL.
RCT Entities:
BACKGROUND: One approach for prevention of cutaneous leishmaniasis (CL) is the creation of a barrier between the insect vector (phlebotoms) and the host. Many but not all researchers claim that permethrin-impregnated uniforms are effective for prevention of CL. We determined the efficacy of permethrin-impregnated uniforms for prevention of CL in Iranian soldiers. METHODS: A total of 324 soldiers were randomized to two equal groups, of which 272 soldiers completed the study. In group A, 134 soldiers were issued permethrin-impregnated uniforms. In group B, 138 soldiers were issued uniforms washed in water. The soldiers wore uniforms day and night for 3 months, and were observed for an additional period of 6 months. All the soldiers remained in the leishmania-endemic area of Isfahan during the 3 months. RESULTS: Nine (6.5%) of 138 soldiers wearing control uniforms and six (4.4%) of 134 soldiers wearing permathrin-impregnated uniforms acquired CL. The difference between two groups was not statistically significant (P < 0.05). CONCLUSION:Permethrin-impregnated uniforms are not effective for the prevention of CL.
Authors: Sarah DeRaedt Banks; James Orsborne; Salvador A Gezan; Harparkash Kaur; Annelies Wilder-Smith; Steve W Lindsey; James G Logan Journal: PLoS Negl Trop Dis Date: 2015-10-06
Authors: Thomas M Mascari; Hanafi A Hanafi; Ryan E Jackson; Souâd Ouahabi; Btissam Ameur; Chafika Faraj; Peter J Obenauer; Joseph W Diclaro; Lane D Foil Journal: PLoS Negl Trop Dis Date: 2013-09-12
Authors: James Orsborne; Sarah DeRaedt Banks; Adam Hendy; Salvador A Gezan; Harparkash Kaur; Annelies Wilder-Smith; Steve W Lindsay; James G Logan Journal: PLoS One Date: 2016-05-17 Impact factor: 3.240