Literature DB >> 1279499

Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene.

L B Giebel1, K M Strunk, S A Holmes, R A Spritz.   

Abstract

We have cloned and sequenced the human KIT proto-oncogene, which contains 21 exons and spans more than 34 kb of DNA on chromosome segment 4q12. We also establish physical linkage between the KIT gene and the related PDGFRA gene. The organization of the KIT gene is virtually identical to that of the homologous FMS gene, located on chromosome 5. Together, these data suggest that the KIT and PDGFRA genes on chromosome 4 and the FMS and PDGFRB genes on chromosome 5 arose by duplication of a common ancestral gene, followed by duplication of a chromosome.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1279499

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  17 in total

1.  Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function.

Authors:  Yashoda Sharma; Clinton M Astle; David E Harrison
Journal:  Exp Hematol       Date:  2007-02       Impact factor: 3.084

2.  Polymerase chain reaction detection of a novel human KIT (mast/stem cell growth factor receptor) gene polymorphism by single-strand conformation polymorphism analysis or by SmaI or BstNI cleavage.

Authors:  R A Spritz; S A Holmes
Journal:  Hum Genet       Date:  1993-09       Impact factor: 4.132

3.  Pigs with the dominant white coat color phenotype carry a duplication of the KIT gene encoding the mast/stem cell growth factor receptor.

Authors:  M Johansson Moller; R Chaudhary; E Hellmén; B Höyheim; B Chowdhary; L Andersson
Journal:  Mamm Genome       Date:  1996-11       Impact factor: 2.957

4.  Platelet-derived growth factor alpha receptor gene expression: isolation and characterization of the promoter and upstream regulatory elements.

Authors:  C Wang; C D Stiles
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205

5.  Genomic structure of the human KDR/flk-1 gene.

Authors:  L Y Yin; Y Wu; C A Ballinger; C Patterson
Journal:  Mamm Genome       Date:  1998-05       Impact factor: 2.957

6.  Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.

Authors:  H Nagata; A S Worobec; C K Oh; B A Chowdhury; S Tannenbaum; Y Suzuki; D D Metcalfe
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

7.  Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c-kit proto-oncogene.

Authors:  Magnus Sundström; Harissios Vliagoftis; Peter Karlberg; Joseph H Butterfield; Kenneth Nilsson; Dean D Metcalfe; Gunnar Nilsson
Journal:  Immunology       Date:  2003-01       Impact factor: 7.397

8.  Tyrosine-kinase mutations in c-KIT and PDGFR-alpha genes of imatinib naïve adult patients with gastrointestinal stromal tumours (GISTs) of the stomach and small intestine: relation to tumour-biological risk-profile and long-term outcome.

Authors:  Kjetil Søreide; Oddvar M Sandvik; Jon Arne Søreide; Einar Gudlaugsson; Kjersti Mangseth; Hans Kristian Haugland
Journal:  Clin Transl Oncol       Date:  2012-07-18       Impact factor: 3.405

9.  Novel mutations and deletions of the KIT (steel factor receptor) gene in human piebaldism.

Authors:  K Ezoe; S A Holmes; L Ho; C P Bennett; J L Bolognia; L Brueton; J Burn; R Falabella; E M Gatto; N Ishii
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

Review 10.  KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis.

Authors:  M Arock; K Sotlar; C Akin; S Broesby-Olsen; G Hoermann; L Escribano; T K Kristensen; H C Kluin-Nelemans; O Hermine; P Dubreuil; W R Sperr; K Hartmann; J Gotlib; N C P Cross; T Haferlach; A Garcia-Montero; A Orfao; J Schwaab; M Triggiani; H-P Horny; D D Metcalfe; A Reiter; P Valent
Journal:  Leukemia       Date:  2015-02-04       Impact factor: 11.528
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.