| Literature DB >> 1279487 |
A Stefani1, P Calabresi, N B Mercuri, G Bernardi.
Abstract
Globus pallidus neurons were dissociated from adult rats and recorded in whole-cell voltage-clamp mode. In tetrodotoxin- and cadmium-added bath, outward potassium conductances were evaluated. Depolarization activated large and predominantly sustained currents, with little inactivation. The transient outward current was isolated through its voltage-dependency, kinetics and pharmacology. A-like current activated around -45 mV and decayed exponentially with a time-constant of about 50 ms at 0 mV. Steady-state half-inactivation voltage was about -60 mV, suggesting that A-current was not fully inactivated at rest. 4-Aminopyridine sensitivity of the transient outward current was in the low millimolar range. A-current might play a relevant role in shaping firing properties of pallidal neurons.Entities:
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Year: 1992 PMID： 1279487 DOI： 10.1016/0304-3940(92)90703-a
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046