Literature DB >> 12794314

The relationship between amyloid and tau.

John Hardy1.   

Abstract

Based on genetic findings, the relationship between the APP/Abeta and tau/tangle pathologies are discussed. It is argued that APP/Abeta is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Abeta can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.

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Year:  2003        PMID： 12794314     DOI： 10.1385/JMN:20:2:203

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  17 in total

Review 1.  Pathways to primary neurodegenerative disease.

Authors:  J Hardy
Journal:  Mayo Clin Proc       Date:  1999-08       Impact factor: 7.616

2.  A stop-codon mutation in the BRI gene associated with familial British dementia.

Authors:  R Vidal; B Frangione; A Rostagno; S Mead; T Révész; G Plant; J Ghiso
Journal:  Nature       Date:  1999-06-24       Impact factor: 49.962

3.  Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

Authors:  E D Carstea; J A Morris; K G Coleman; S K Loftus; D Zhang; C Cummings; J Gu; M A Rosenfeld; W J Pavan; D B Krizman; J Nagle; M H Polymeropoulos; S L Sturley; Y A Ioannou; M E Higgins; M Comly; A Cooney; A Brown; C R Kaneski; E J Blanchette-Mackie; N K Dwyer; E B Neufeld; T Y Chang; L Liscum; J F Strauss; K Ohno; M Zeigler; R Carmi; J Sokol; D Markie; R R O'Neill; O P van Diggelen; M Elleder; M C Patterson; R O Brady; M T Vanier; P G Pentchev; D A Tagle
Journal:  Science       Date:  1997-07-11       Impact factor: 47.728

4.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

Authors:  A Goate; M C Chartier-Harlin; M Mullan; J Brown; F Crawford; L Fidani; L Giuffra; A Haynes; N Irving; L James
Journal:  Nature       Date:  1991-02-21       Impact factor: 49.962

5.  Susceptibility locus for Alzheimer's disease on chromosome 10.

Authors:  A Myers; P Holmans; H Marshall; J Kwon; D Meyer; D Ramic; S Shears; J Booth; F W DeVrieze; R Crook; M Hamshere; R Abraham; N Tunstall; F Rice; S Carty; S Lillystone; P Kehoe; V Rudrasingham; L Jones; S Lovestone; J Perez-Tur; J Williams; M J Owen; J Hardy; A M Goate
Journal:  Science       Date:  2000-12-22       Impact factor: 47.728

6.  Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.

Authors:  D Games; D Adams; R Alessandrini; R Barbour; P Berthelette; C Blackwell; T Carr; J Clemens; T Donaldson; F Gillespie
Journal:  Nature       Date:  1995-02-09       Impact factor: 49.962

7.  Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.

Authors:  C F Lippa; H Fujiwara; D M Mann; B Giasson; M Baba; M L Schmidt; L E Nee; B O'Connell; D A Pollen; P St George-Hyslop; B Ghetti; D Nochlin; T D Bird; N J Cairns; V M Lee; T Iwatsubo; J Q Trojanowski
Journal:  Am J Pathol       Date:  1998-11       Impact factor: 4.307

8.  Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.

Authors:  J D Brook; M E McCurrach; H G Harley; A J Buckler; D Church; H Aburatani; K Hunter; V P Stanton; J P Thirion; T Hudson
Journal:  Cell       Date:  1992-02-21       Impact factor: 41.582

9.  Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice.

Authors:  M A Leissring; Y Akbari; C M Fanger; M D Cahalan; M P Mattson; F M LaFerla
Journal:  J Cell Biol       Date:  2000-05-15       Impact factor: 10.539

10.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

Authors:  R Sherrington; E I Rogaev; Y Liang; E A Rogaeva; G Levesque; M Ikeda; H Chi; C Lin; G Li; K Holman; T Tsuda; L Mar; J F Foncin; A C Bruni; M P Montesi; S Sorbi; I Rainero; L Pinessi; L Nee; I Chumakov; D Pollen; A Brookes; P Sanseau; R J Polinsky; W Wasco; H A Da Silva; J L Haines; M A Perkicak-Vance; R E Tanzi; A D Roses; P E Fraser; J M Rommens; P H St George-Hyslop
Journal:  Nature       Date:  1995-06-29       Impact factor: 49.962
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  20 in total

Review 1.  Some evolutionary perspectives on Alzheimer's disease pathogenesis and pathology.

Authors:  Daniel J Glass; Steven E Arnold
Journal:  Alzheimers Dement       Date:  2011-12-03       Impact factor: 21.566

2.  Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion Dependency.

Authors:  Ashley J Mason; Ian Hurst; Ravinder Malik; Ibrar Siddique; Inna Solomonov; Irit Sagi; Frank-Gerrit Klärner; Thomas Schrader; Gal Bitan
Journal:  ACS Chem Neurosci       Date:  2020-07-07       Impact factor: 4.418

3.  Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.

Authors:  Joao P Lopes; Catarina R Oliveira; Paula Agostinho
Journal:  Cell Mol Neurobiol       Date:  2007-10-27       Impact factor: 5.046

Review 4.  The end of Alzheimer's disease--from biochemical pharmacology to ecopsychosociology: a personal perspective.

Authors:  Peter J Whitehouse
Journal:  Biochem Pharmacol       Date:  2013-12-01       Impact factor: 5.858

5.  A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons.

Authors:  Ya-Li Zheng; Sashi Kesavapany; Maneth Gravell; Rebecca S Hamilton; Manfred Schubert; Niranjana Amin; Wayne Albers; Philip Grant; Harish C Pant
Journal:  EMBO J       Date:  2004-12-09       Impact factor: 11.598

Review 6.  The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease.

Authors:  Laura J Blair; Jeremy D Baker; Jonathan J Sabbagh; Chad A Dickey
Journal:  J Neurochem       Date:  2015-02-24       Impact factor: 5.372

7.  Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.

Authors:  Xue-Yang Jiang; Ting-Kai Chen; Jun-Ting Zhou; Si-Yu He; Hong-Yu Yang; Yao Chen; Wei Qu; Feng Feng; Hao-Peng Sun
Journal:  ACS Med Chem Lett       Date:  2018-02-09       Impact factor: 4.345

8.  Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Authors:  Michael A Myre; Kevin Washicosky; Robert D Moir; Giuseppina Tesco; Rudolph E Tanzi; Wilma Wasco
Journal:  Cell Signal       Date:  2008-12-25       Impact factor: 4.315

9.  Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.

Authors:  Amanda Hanna; Kayleigh Iremonger; Pritam Das; Dennis Dickson; Todd Golde; Christopher Janus
Journal:  Alzheimers Res Ther       Date:  2012-06-14       Impact factor: 6.982

Review 10.  Mechanism-based treatments for Alzheimer's disease.

Authors:  Peter Davies; Jeremy Koppel
Journal:  Dialogues Clin Neurosci       Date:  2009       Impact factor: 5.986
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