OBJECTIVE: Very low birth weight premature children often show cognitive development abnormalities. There is scarce information about the outcome of these children at preschool age in Brazil. The objective of the study is to describe the cognitive development of a population of premature newborns and to assess possible prognostic factors for abnormalities. METHODS: A cohort study was conducted in a preschool children population whose subjects were very low birth weight premature babies born between January 1991 and September 1993. WPPSI-R Test was used for cognitive evaluation and it was applied by psychologists. Two cut-offs were set to describe abnormality: scores below 1 and 2 standard deviations (SD). RESULTS: Seventy-nine children aged 4 and 5 years were studied. The mean full WIPPSI-R score was 75.6 (+/-11.9). The incidence of abnormal 1 and 2 SD full score was 77.2% and 32.9%, respectively. After adjusting for the method of delivery, small for gestational age (OR=6.19, 95% CI 1.60-23.86), abnormal cerebral ultrasound exam (OR=5.90, 95% CI 1.04-9.83) and male sex (OR=3.20, 95% CI 1.32-26.35) were predictors of full score <70. CONCLUSIONS: Compared to the literature, these children showed a more severe cognitive development impairment. Small for gestational age, abnormal cerebral ultrasound exam and male sex were prognostic factors for worse outcome.
OBJECTIVE: Very low birth weight premature children often show cognitive development abnormalities. There is scarce information about the outcome of these children at preschool age in Brazil. The objective of the study is to describe the cognitive development of a population of premature newborns and to assess possible prognostic factors for abnormalities. METHODS: A cohort study was conducted in a preschool children population whose subjects were very low birth weight premature babies born between January 1991 and September 1993. WPPSI-R Test was used for cognitive evaluation and it was applied by psychologists. Two cut-offs were set to describe abnormality: scores below 1 and 2 standard deviations (SD). RESULTS: Seventy-nine children aged 4 and 5 years were studied. The mean full WIPPSI-R score was 75.6 (+/-11.9). The incidence of abnormal 1 and 2 SD full score was 77.2% and 32.9%, respectively. After adjusting for the method of delivery, small for gestational age (OR=6.19, 95% CI 1.60-23.86), abnormal cerebral ultrasound exam (OR=5.90, 95% CI 1.04-9.83) and male sex (OR=3.20, 95% CI 1.32-26.35) were predictors of full score <70. CONCLUSIONS: Compared to the literature, these children showed a more severe cognitive development impairment. Small for gestational age, abnormal cerebral ultrasound exam and male sex were prognostic factors for worse outcome.
Authors: Lucie Švandová; Radek Ptáček; Martina Vňuková; Hana Ptáčková; Martin Anders; Petr Bob; Simon Weissenberger; Daniela Marková; Ivan Sebalo; Jiří Raboch; Michal Goetz Journal: Med Sci Monit Date: 2022-03-29
Authors: Darci N Santos; Ana Marlúcia O Assis; Ana Cecília S Bastos; Letícia M Santos; Carlos Antonio St Santos; Agostino Strina; Matildes S Prado; Naomar M Almeida-Filho; Laura C Rodrigues; Mauricio L Barreto Journal: BMC Public Health Date: 2008-06-06 Impact factor: 3.295
Authors: Miguel Pérez-Pereira; María Pilar Fernández; María Luisa Gómez-Taibo; Zeltia Martínez-López; Constantino Arce Journal: Int J Environ Res Public Health Date: 2020-03-31 Impact factor: 3.390