Monika A Malecha1, Robert S Wilroy Jr. 1. Department of Opthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA. mmalecha@mail.eye.utmem.edu
Abstract
PURPOSE: To report unusual bilateral corneal opacity and inferior corneal thinning in a patient with idiopathic multicentric osteolysis. METHODS: A 17-year-old girl with a history of idiopathic multicentric osteolysis was evaluated for corneal opacities. RESULTS: She was found to have bilateral, linear, posterior corneal opacity and inferior corneal thinning. Her vision did not appear to be affected. No progression of the corneal findings was noted over a period of 2 years. CONCLUSION: Posterior corneal opacity and inferior corneal thinning may be associated with idiopathic multicentric osteolysis, a rare disorder of unknown etiology characterized by bony abnormalities and nephropathy. Patients with idiopathic multicentric osteolysis should be evaluated by an ophthalmologist for the presence of corneal opacities.
PURPOSE: To report unusual bilateral corneal opacity and inferior corneal thinning in a patient with idiopathic multicentric osteolysis. METHODS: A 17-year-old girl with a history of idiopathic multicentric osteolysis was evaluated for corneal opacities. RESULTS: She was found to have bilateral, linear, posterior corneal opacity and inferior corneal thinning. Her vision did not appear to be affected. No progression of the corneal findings was noted over a period of 2 years. CONCLUSION: Posterior corneal opacity and inferior corneal thinning may be associated with idiopathic multicentric osteolysis, a rare disorder of unknown etiology characterized by bony abnormalities and nephropathy. Patients with idiopathic multicentric osteolysis should be evaluated by an ophthalmologist for the presence of corneal opacities.
Authors: Steven Mumm; Margaret Huskey; Shenghui Duan; Deborah Wenkert; Katherine L Madson; Gary S Gottesman; Angela R Nenninger; Ronald M Laxer; William H McAlister; Michael P Whyte Journal: Am J Med Genet A Date: 2014-07-02 Impact factor: 2.802