Literature DB >> 12790602

Expedient acylations of primary and secondary alkyl cyanides to alpha-substituted beta-ketonitriles.

Alan R Katritzky1, Ashraf A A Abdel-Fattah, Mingyi Wang.   

Abstract

Primary and secondary cyanides are efficiently acylated with N-acylbenzotriazoles 3a-f (derived from a variety of acids) to afford the corresponding alpha-substituted beta-ketonitriles 5a-r in 67-96% yields.

Entities:  

Year:  2003        PMID： 12790602     DOI： 10.1021/jo026796x

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist.

Authors:  Haijun Chen; Chunyong Ding; Christopher Wild; Huiling Liu; Tianzhi Wang; Mark A White; Xiaodong Cheng; Jia Zhou
Journal:  Tetrahedron Lett       Date:  2013-03-20       Impact factor: 2.415

2.  Silicon Industry Waste Polymethylhydrosiloxane-Mediated Benzotriazole Ring Cleavage: A Practical and Green Synthesis of Diverse Benzothiazoles.

Authors:  Mangal S Yadav; Anoop S Singh; Anand K Agrahari; Nidhi Mishra; Vinod K Tiwari
Journal:  ACS Omega       Date:  2019-04-11
  2 in total

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