| Literature DB >> 12790559 |
Philip Magnus1, Kenneth S Matthews, Vince Lynch.
Abstract
[reaction: see text] A general strategy for the formation of 1,3-cis-substituted tetrahydroisoquinolines is described from ortho-iodo imines involving Larock isoquinoline synthesis, addition of organolithium compounds to unactivated isoquinolines, and ionic hydrogenation. In addition, a new synthesis of lactams via an unprecedented azide cyclization in the presence of a sulfonium ion is described.Entities:
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Year: 2003 PMID： 12790559 DOI： 10.1021/ol034683+
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005