Literature DB >> 12790537

Synthetic studies on ecteinascidin-743: constructing a versatile pentacyclic intermediate for the synthesis of ecteinascidins and saframycins.

Wei Jin1, Sammy Metobo, Robert M Williams.   

Abstract

[reaction: see text] The asymmetric synthesis of a highly functionalized pentacyclic tetrahydroisoquinoline relevant to the ecteinascidin, saframycin, safracin, and renieramycin family of antitumor alkaloids is described.

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Year:  2003        PMID： 12790537     DOI： 10.1021/ol034575n

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Regioselectivity of Pictet-Spengler Cyclization Reactions to Construct the Pentacyclic Frameworks of the Ecteinascidin-Saframycin Class of Tetrahydroisoquinoline Antitumor Antibiotics.

Authors:  Guillaume Vincent; Jonathan W Lane; Robert M Williams
Journal:  Tetrahedron Lett       Date:  2007-05-21       Impact factor: 2.415

2.  Synthetic studies on Et-743. Assembly of the pentacyclic core and a formal total synthesis.

Authors:  Dan Fishlock; Robert M Williams
Journal:  J Org Chem       Date:  2008-12-19       Impact factor: 4.354

3.  Draft genome sequence analysis of a Pseudomonas putida W15Oct28 strain with antagonistic activity to Gram-positive and Pseudomonas sp. pathogens.

Authors:  Lumeng Ye; Falk Hildebrand; Jozef Dingemans; Steven Ballet; George Laus; Sandra Matthijs; Roeland Berendsen; Pierre Cornelis
Journal:  PLoS One       Date:  2014-11-04       Impact factor: 3.240
  3 in total

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