Literature DB >> 1278934

The effect of Leishmania tropica on stimulation of lymphocytes with phytohaemagglutinin.

F S Farah, S Lazary, A de Weck.   

Abstract

Cell-mediated immune (CMI) responses are important in the immunity against leishmanial infections. However, infection persists in the presence of CMI for unknown reasons. Evidence is presented that L. tropica and its products are capable of inhibition of the stimulation of lymphocytes by PHA. This inhibition is dose dependent, and not dependent on competition for nutrients in the medium, nor on neutralization of PHA. The inhibition is observed on the lymphocytes of species susceptible to leishmanial infection, and not operative in resistant species. The mechanisms of the lymphocyte suppression are discussed.

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Year:  1976        PMID： 1278934      PMCID： PMC1445040     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  14 in total

1.  Major changes in lymphocyte proliferation evoked by activated macrophages.

Authors:  R Keller
Journal:  Cell Immunol       Date:  1975-06       Impact factor: 4.868

2.  Inhibition of 3H-thymidine incorporation of lymphocytes by a soluble factor from macrophages.

Authors:  H G Opitz; D Niethammer; H Lemke; H D Flad; R Huget
Journal:  Cell Immunol       Date:  1975-04       Impact factor: 4.868

3.  Experimental cutaneous leishmaniasis. 3. Effects of thymectomy on the course of infection of CBA mice with Leishmania tropica.

Authors:  P M Preston; R L Carter; E Leuchars; A J Davies; D C Dumonde
Journal:  Clin Exp Immunol       Date:  1972-02       Impact factor: 4.330

4.  The effect of prolonged treatment with antilymphocyte serum on the course of infections with BCG and Leishmania enriettii in the guinea-pig.

Authors:  A D Bryceson; J L Turk
Journal:  J Pathol       Date:  1971-07       Impact factor: 7.996

5.  Inhibition of lymphocyte transformation induced by phytohaemagglutinin with porcine mycoplasma.

Authors:  D H Roberts
Journal:  Br Vet J       Date:  1972-11

6.  Observations on the susceptibility of white mice to infection with Leishmania mexicana following whole-body x-irradiation.

Authors:  J J Shaw; A Voller
Journal:  Ann Trop Med Parasitol       Date:  1968-06

7.  Cutaneous leishmaniasis in the guinea pig. Delayed-type hypersensitivity, lymphocyte stimulation, and inhibition of macrophage migration.

Authors:  T M Blewett; D M Kadivar; E J Soulsby
Journal:  Am J Trop Med Hyg       Date:  1971-07       Impact factor: 2.345

8.  The role of the macrophage in cutaneous leishmaniasis.

Authors:  F S Farah; S A Samra; N Nuwayri-Salti
Journal:  Immunology       Date:  1975-10       Impact factor: 7.397

9.  Cellular immunity to Leishmania donovani. I. The effect of T cell depletion on resistance to L. donovani in mice.

Authors:  C B Skov; D W Twohy
Journal:  J Immunol       Date:  1974-12       Impact factor: 5.422

10.  Cellular immunity to Leishmania donovani. II. Evidence for synergy between thymocytes and lymph node cells in reconstitution of acquired resistance to L. donovani in mice.

Authors:  C B Skov; D W Twohy
Journal:  J Immunol       Date:  1974-12       Impact factor: 5.422
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  4 in total

1.  In vitro lymphocyte stimulation in leprosy; simultaneous stimulation with Mycobacterium leprae antigens and phytohaemagglutinin.

Authors:  G Bjune
Journal:  Clin Exp Immunol       Date:  1979-06       Impact factor: 4.330

2.  In vitro suppression of lymphocyte blastogenic response to mitogen and antigen by Leishmania tropica.

Authors:  M K Sharma; F Anaraki; F Ala
Journal:  Clin Exp Immunol       Date:  1978-06       Impact factor: 4.330

3.  [Dynamics of splenic lymphocytes and immunosuppression in Toxoplasma infected mice (author's transl)].

Authors:  B Pelster
Journal:  Z Parasitenkd       Date:  1980

4.  Serum protein from Leishmania brasiliensis infected hamster that suppress lymphocyte response of normal hamster lymphocytes.

Authors:  J A O'Daly; Z Cabrera
Journal:  Z Parasitenkd       Date:  1986
  4 in total

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