OBJECTIVE: A retrospective study was conducted to investigate the anatomic location and characteristics of amyloid deposition in the oral cavity. STUDY DESIGN: Seventeen biopsy specimens that were conclusive for a diagnosis of amyloidosis were assessed in terms of their anatomic location and histopathologic characteristics. RESULTS: Biopsy specimens were received from 13 patients-9 females and 4 males. Six specimens were taken from the buccal mucosa, 4 from the tongue, 3 from the palate, 2 from the gingiva, and 2 from the floor of the mouth. Fifteen of 17 specimens (88%) had amyloid deposition in the subepithelial connective tissue in all locations. CONCLUSION: On the basis of our pilot data, a previously overlooked intraoral anatomic location, the buccal mucosa, may prove to be of higher diagnostic value than others previously reported in terms of obtaining a diagnosis of amyloidosis. In addition, the manner in which tissue biopsies are conducted for amyloid detection may be altered to create less morbidity.
OBJECTIVE: A retrospective study was conducted to investigate the anatomic location and characteristics of amyloid deposition in the oral cavity. STUDY DESIGN: Seventeen biopsy specimens that were conclusive for a diagnosis of amyloidosis were assessed in terms of their anatomic location and histopathologic characteristics. RESULTS: Biopsy specimens were received from 13 patients-9 females and 4 males. Six specimens were taken from the buccal mucosa, 4 from the tongue, 3 from the palate, 2 from the gingiva, and 2 from the floor of the mouth. Fifteen of 17 specimens (88%) had amyloid deposition in the subepithelial connective tissue in all locations. CONCLUSION: On the basis of our pilot data, a previously overlooked intraoral anatomic location, the buccal mucosa, may prove to be of higher diagnostic value than others previously reported in terms of obtaining a diagnosis of amyloidosis. In addition, the manner in which tissue biopsies are conducted for amyloid detection may be altered to create less morbidity.
Authors: Thorsten Send; Jennifer L Spiegel; Goetz Schade; Annette Pantelis; Arno Olthoff; Friedrich Bootz; Martin Canis; Mark Jakob Journal: Dysphagia Date: 2018-10-31 Impact factor: 3.438
Authors: Flávia Sayuri Matsuo; Luiz Fernando Barbosa de Paulo; João Paulo Silva Servato; Paulo Rogério de Faria; Sergio Vitorino Cardoso; Adriano Mota Loyola Journal: Clin Oral Investig Date: 2015-11-10 Impact factor: 3.573
Authors: Luiz Antonio Liarte Marconcini; Forrest Marc Stewart; Lisa Sonntag; Emily Stevens; Nicholas Burwick Journal: Case Rep Hematol Date: 2015-05-07