Literature DB >> 12788456

Synthesis and characterization of novel dipeptide ester prodrugs of acyclovir.

Yasser E Nashed1, Ashim K Mitra.   

Abstract

Four dipeptide (Gly-Gly, Gly-Val, Val-Val, Val-Gly) ester prodrugs of 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir, ACV) were synthesized. LC/MS was used to characterize the new prodrugs. Both 1H NMR and 13C NMR spectra of the four prodrugs of ACV were measured and assigned based on spectral comparison with compounds of similar structures.

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Year:  2003        PMID： 12788456     DOI： 10.1016/s1386-1425(03)00007-6

Source DB:  PubMed          Journal:  Spectrochim Acta A Mol Biomol Spectrosc        ISSN： 1386-1425            Impact factor:   4.098


  6 in total

1.  Serine side chain-linked peptidomimetic conjugates of cyclic HPMPC and HPMPA: synthesis and interaction with hPEPT1.

Authors:  Larryn W Peterson; Monica Sala-Rabanal; Ivan S Krylov; Michaela Serpi; Boris A Kashemirov; Charles E McKenna
Journal:  Mol Pharm       Date:  2010-10-07       Impact factor: 4.939

2.  Disposition kinetics of a dipeptide ester prodrug of acyclovir and its metabolites following intravenous and oral administrations in rat.

Authors:  Ravi S Talluri; Ripal Gaudana; Sudharshan Hariharan; Ritesh Jain; Ashim K Mitra
Journal:  Clin Res Regul Aff       Date:  2009-01-01

Review 3.  Prodrug strategies in ocular drug delivery.

Authors:  Megha Barot; Mahuya Bagui; Mitan R Gokulgandhi; Ashim K Mitra
Journal:  Med Chem       Date:  2012-07       Impact factor: 2.745

Review 4.  Amino Acids in the Development of Prodrugs.

Authors:  Nuno Vale; Abigail Ferreira; Joana Matos; Paula Fresco; Maria João Gouveia
Journal:  Molecules       Date:  2018-09-11       Impact factor: 4.411

5.  Ocular sustained release nanoparticles containing stereoisomeric dipeptide prodrugs of acyclovir.

Authors:  Jwala Jwala; Sai H S Boddu; Sujay Shah; Suman Sirimulla; Dhananjay Pal; Ashim K Mitra
Journal:  J Ocul Pharmacol Ther       Date:  2011-04       Impact factor: 2.671

6.  Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir.

Authors:  Ravi S Talluri; Swapan K Samanta; Ripal Gaudana; Ashim K Mitra
Journal:  Int J Pharm       Date:  2008-06-23       Impact factor: 5.875
  6 in total

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