Literature DB >> 12788343

Superoxide dismutase mimetics. Part 2: synthesis and structure-activity relationship of glyoxylate- and glyoxamide-derived metalloporphyrins.

Michael P Trova1, Polivina Jolicia F Gauuan, Anthony D Pechulis, Stephen M Bubb, Stephen B Bocckino, James D Crapo, Brian J Day.   

Abstract

Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26-58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32, 39, and 54 and glyoxamide-derived metalloporphyrin 49, exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity.

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Year:  2003        PMID： 12788343     DOI： 10.1016/s0968-0896(03)00272-4

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  15 in total

1.  Superoxide dismutase mimics.

Authors:  Rosalind A Rosenthal; Susan R Doctrow; Wyeth B Callaway
Journal:  Antioxid Redox Signal       Date:  2011-03-15       Impact factor: 8.401

2.  Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson's disease.

Authors:  Li-Ping Liang; Jie Huang; Ruth Fulton; Jennifer N Pearson-Smith; Brian J Day; Manisha Patel
Journal:  Toxicol Appl Pharmacol       Date:  2017-04-08       Impact factor: 4.219

3.  Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells.

Authors:  Ursula Andreo; Josh Elkind; Courtney Blachford; Arthur I Cederbaum; Edward A Fisher
Journal:  FASEB J       Date:  2011-07-14       Impact factor: 5.191

4.  Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: attenuation by a lipophilic metalloporphyrin.

Authors:  Li-Ping Liang; Simon Waldbaum; Shane Rowley; Ting-Ting Huang; Brian J Day; Manisha Patel
Journal:  Neurobiol Dis       Date:  2011-12-16       Impact factor: 5.996

Review 5.  Salen Mn complexes mitigate radiation injury in normal tissues.

Authors:  Rosalind A Rosenthal; Brian Fish; Richard P Hill; Karl D Huffman; Zelmira Lazarova; Javed Mahmood; Meetha Medhora; Robert Molthen; John E Moulder; Stephen T Sonis; Philip J Tofilon; Susan R Doctrow
Journal:  Anticancer Agents Med Chem       Date:  2011-05-01       Impact factor: 2.505

6.  A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.

Authors:  Artak Tovmasyan; Clarissa G C Maia; Tin Weitner; Sebastián Carballal; Romulo S Sampaio; Dominik Lieb; Robert Ghazaryan; Ivana Ivanovic-Burmazovic; Gerardo Ferrer-Sueta; Rafael Radi; Julio S Reboucas; Ivan Spasojevic; Ludmil Benov; Ines Batinic-Haberle
Journal:  Free Radic Biol Med       Date:  2015-05-28       Impact factor: 7.376

Review 7.  Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential.

Authors:  Ines Batinić-Haberle; Júlio S Rebouças; Ivan Spasojević
Journal:  Antioxid Redox Signal       Date:  2010-09-15       Impact factor: 8.401

8.  Synthesis of porphyrins bearing 1-4 hydroxymethyl groups and other one-carbon oxygenic substituents in distinct patterns.

Authors:  Zhen Yao; Jayeeta Bhaumik; Savithri Dhanalekshmi; Marcin Ptaszek; Phillip A Rodriguez; Jonathan S Lindsey
Journal:  Tetrahedron       Date:  2007-10-22       Impact factor: 2.457

9.  Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins.

Authors:  Pablo R Castello; Derek A Drechsel; Brian J Day; Manisha Patel
Journal:  J Pharmacol Exp Ther       Date:  2007-12-06       Impact factor: 4.030

10.  Orally available Mn porphyrins with superoxide dismutase and catalase activities.

Authors:  Rosalind A Rosenthal; Karl D Huffman; Leslie W Fisette; Christy A Damphousse; Wyeth B Callaway; Bernard Malfroy; Susan R Doctrow
Journal:  J Biol Inorg Chem       Date:  2009-06-06       Impact factor: 3.358
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