Literature DB >> 12787793

Finding genes underlying risk of complex disease by linkage disequilibrium mapping.

Andrew G Clark1.   

Abstract

Identification of genes that harbor variation associated with inter-individual differences in risk of complex diseases remains one of the most challenging and important problems in human genetics. For genetic variants that are sufficiently common and have sufficiently large effects, direct tests of association through linkage disequilibrium with anonymous SNPs may prove effective. But the two critical parameters - the frequency of risk-inflating alleles and the magnitudes of their effect on risk - remain largely unknown. In this review we consider the latest information regarding the likely efficacy of the linkage disequilibrium mapping approach.

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Year:  2003        PMID： 12787793     DOI： 10.1016/s0959-437x(03)00056-x

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  14 in total

1.  Does haplotype diversity predict power for association mapping of disease susceptibility?

Authors:  Weihua Zhang; Andrew Collins; Newton E Morton
Journal:  Hum Genet       Date:  2004-06-04       Impact factor: 4.132

2.  The allele frequency spectrum in genome-wide human variation data reveals signals of differential demographic history in three large world populations.

Authors:  Gabor T Marth; Eva Czabarka; Janos Murvai; Stephen T Sherry
Journal:  Genetics       Date:  2004-01       Impact factor: 4.562

Review 3.  Linkage disequilibrium and association studies in higher plants: present status and future prospects.

Authors:  Pushpendra K Gupta; Sachin Rustgi; Pawan L Kulwal
Journal:  Plant Mol Biol       Date:  2005-03       Impact factor: 4.076

Review 4.  Evaluating HapMap SNP data transferability in a large-scale genotyping project involving 175 cancer-associated genes.

Authors:  Gloria Ribas; Anna González-Neira; Antonio Salas; Roger L Milne; Ana Vega; Begoña Carracedo; Emilio González; Eva Barroso; Lara P Fernández; Patricio Yankilevich; Mercedes Robledo; Angel Carracedo; Javier Benítez
Journal:  Hum Genet       Date:  2005-12-02       Impact factor: 4.132

5.  A general population-genetic model for the production by population structure of spurious genotype-phenotype associations in discrete, admixed or spatially distributed populations.

Authors:  Noah A Rosenberg; Magnus Nordborg
Journal:  Genetics       Date:  2006-04-02       Impact factor: 4.562

6.  Algorithms to distinguish the role of gene-conversion from single-crossover recombination in the derivation of SNP sequences in populations.

Authors:  Yun S Song; Zhihong Ding; Dan Gusfield; Charles H Langley; Yufeng Wu
Journal:  J Comput Biol       Date:  2007-12       Impact factor: 1.479

7.  A decomposition theory for phylogenetic networks and incompatible characters.

Authors:  Dan Gusfield; Vikas Bansal; Vineet Bafna; Yun S Song
Journal:  J Comput Biol       Date:  2007-12       Impact factor: 1.479

8.  A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases.

Authors:  P-Y Liu; Y-Y Zhang; Y Lu; J-R Long; H Shen; Lan-J Zhao; F-H Xu; P Xiao; D-H Xiong; Y-J Liu; R R Recker; H-W Deng
Journal:  J Med Genet       Date:  2005-03       Impact factor: 6.318

9.  Signatures of selection and gene conversion associated with human color vision variation.

Authors:  Brian C Verrelli; Sarah A Tishkoff
Journal:  Am J Hum Genet       Date:  2004-07-13       Impact factor: 11.025

10.  Correlation of population parameters leading to power differences in association studies with population stratification.

Authors:  Y He; R Jiang; W Fu; A W Bergen; G E Swan; L Jin
Journal:  Ann Hum Genet       Date:  2008-07-24       Impact factor: 1.670
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