Literature DB >> 12787757

Negative regulation of TCR signaling and T-cell activation by selective protein degradation.

Ihn-Kyung Jang1, Hua Gu.   

Abstract

Protein degradation was previously considered to be a nonspecific cellular process that eradicated abnormal or damaged proteins. Current evidence indicates, however, that T cells use this mechanism to selectively eliminate activated T-cell receptors (TCRs) and signaling molecules, and consequently control the duration and specificity of TCR signaling.

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Year:  2003        PMID： 12787757     DOI： 10.1016/s0952-7915(03)00048-7

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  19 in total

1.  NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease.

Authors:  Nobuyoshi Hanaoka; Bana Jabri; Zhenpeng Dai; Cezary Ciszewski; Anne M Stevens; Cassian Yee; Hideki Nakakuma; Thomas Spies; Veronika Groh
Journal:  J Immunol       Date:  2010-10-06       Impact factor: 5.422

2.  A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling.

Authors:  Anatoly Mikhailik; Bradley Ford; James Keller; Yunting Chen; Nicolas Nassar; Nick Carpino
Journal:  Mol Cell       Date:  2007-08-03       Impact factor: 17.970

3.  Increased T-cell reactivity and elevated levels of CD8+ memory T-cells in Alzheimer's disease-patients and T-cell hyporeactivity in an Alzheimer's disease-mouse model: implications for immunotherapy.

Authors:  Katharina Schindowski; Anne Eckert; Jürgen Peters; Corinna Gorriz; Uta Schramm; Thomas Weinandi; Konrad Maurer; Lutz Frölich; Walter E Müller
Journal:  Neuromolecular Med       Date:  2007-10-26       Impact factor: 3.843

4.  c-Cbl-mediated regulation of LAT-nucleated signaling complexes.

Authors:  Lakshmi Balagopalan; Valarie A Barr; Connie L Sommers; Mira Barda-Saad; Amrita Goyal; Matthew S Isakowitz; Lawrence E Samelson
Journal:  Mol Cell Biol       Date:  2007-10-15       Impact factor: 4.272

5.  Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.

Authors:  Lakshmi Balagopalan; Benjamin A Ashwell; Kelsie M Bernot; Itoro O Akpan; Naeha Quasba; Valarie A Barr; Lawrence E Samelson
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-31       Impact factor: 11.205

6.  Alpha-MSH regulates protein ubiquitination in T cells.

Authors:  D J Biros; K Namba; A W Taylor
Journal:  Cell Mol Biol (Noisy-le-grand)       Date:  2006-05-30       Impact factor: 1.770

Review 7.  c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.

Authors:  Christine B F Thien; Wallace Y Langdon
Journal:  Biochem J       Date:  2005-10-15       Impact factor: 3.857

8.  Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.

Authors:  Krzysztof Laudanski; Carol Miller-Graziano; Wenzhong Xiao; Michael N Mindrinos; Daniel R Richards; Asit De; Lyle L Moldawer; Ronald V Maier; Paul Bankey; Henry V Baker; Bernard H Brownstein; J Perren Cobb; Steve E Calvano; Ronald W Davis; Ronald G Tompkins
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-10       Impact factor: 11.205

Review 9.  Endocytic events in TCR signaling: focus on adapters in microclusters.

Authors:  Lakshmi Balagopalan; Valarie A Barr; Lawrence E Samelson
Journal:  Immunol Rev       Date:  2009-11       Impact factor: 12.988

10.  The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.

Authors:  Nick Carpino; Yunting Chen; Nicolas Nassar; Hye-Won Oh
Journal:  Mol Immunol       Date:  2009-09-05       Impact factor: 4.407
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