OBJECTIVES: The purpose of this study was to determine to what extent the presence or absence of periodontal pathogens can distinguish between subjects with chronic and aggressive periodontitis. MATERIAL AND METHODS: A systematic review of cross sectional and longitudinal studies providing microbiological data both from patients with chronic periodontitis (ChP) and aggressive periodontitis (AgP) at a subject level. Strict inclusion criteria were applied. The presence or absence of five microorganisms was selected as primary study parameters: Actinobacillus actinomycetemcomitans (AA), Porphyromonas gingivalis (PG), Prevotella intermedia (PI), Bacteroides forsythus (BF), and Campylobacter rectus (CR). RESULTS: The presence or absence of AA could be evaluated in 11 papers. In seven papers the presence or absence of PG could be analysed. Subject specific data on PI were available from six studies. Two studies could be used regarding the presence or absence of BF, and two regarding CR. Sensitivity and specificity of every microbiological test were individually calculated for each selected study, assuming that the clinical diagnosis of AgP or ChP was the true status the tests attempted to detect. AgP was considered to be the condition of interest and ChP was considered equivalent to 'non-AgP'. Receiver Operator Characteristic (ROC) diagrams were constructed using these data. ROC diagrams indicated the limited discriminatory ability of all of the test parameters to identify subjects with AgP. An additional assessment showed that the highly leukotoxic variant of AA was uniquely associated with patients suffering from aggressive periodontitis. However, in a high proportion of patients diagnosed with AgP the presence of this variant could not be detected. CONCLUSION: The presence or absence of AA, PG, PI, BF or CR could not discriminate between subjects with AgP from those with ChP.
OBJECTIVES: The purpose of this study was to determine to what extent the presence or absence of periodontal pathogens can distinguish between subjects with chronic and aggressive periodontitis. MATERIAL AND METHODS: A systematic review of cross sectional and longitudinal studies providing microbiological data both from patients with chronic periodontitis (ChP) and aggressive periodontitis (AgP) at a subject level. Strict inclusion criteria were applied. The presence or absence of five microorganisms was selected as primary study parameters: Actinobacillus actinomycetemcomitans (AA), Porphyromonas gingivalis (PG), Prevotella intermedia (PI), Bacteroides forsythus (BF), and Campylobacter rectus (CR). RESULTS: The presence or absence of AA could be evaluated in 11 papers. In seven papers the presence or absence of PG could be analysed. Subject specific data on PI were available from six studies. Two studies could be used regarding the presence or absence of BF, and two regarding CR. Sensitivity and specificity of every microbiological test were individually calculated for each selected study, assuming that the clinical diagnosis of AgP or ChP was the true status the tests attempted to detect. AgP was considered to be the condition of interest and ChP was considered equivalent to 'non-AgP'. Receiver Operator Characteristic (ROC) diagrams were constructed using these data. ROC diagrams indicated the limited discriminatory ability of all of the test parameters to identify subjects with AgP. An additional assessment showed that the highly leukotoxic variant of AA was uniquely associated with patients suffering from aggressive periodontitis. However, in a high proportion of patients diagnosed with AgP the presence of this variant could not be detected. CONCLUSION: The presence or absence of AA, PG, PI, BF or CR could not discriminate between subjects with AgP from those with ChP.
Authors: Walter J Psoter; Yao Ge; Stefanie L Russell; Zhou Chen; Ralph V Katz; Germain Jean-Charles; Yihong Li Journal: Clin Oral Investig Date: 2010-05-06 Impact factor: 3.573
Authors: R J Genco; M J LaMonte; D I McSkimming; M J Buck; L Li; K M Hovey; C A Andrews; Y Sun; M Tsompana; W Zheng; H R Banack; V Murugaiyan; J Wactawski-Wende Journal: J Dent Res Date: 2019-08 Impact factor: 6.116
Authors: Brian M Peters; Mary Ann Jabra-Rizk; Graeme A O'May; J William Costerton; Mark E Shirtliff Journal: Clin Microbiol Rev Date: 2012-01 Impact factor: 26.132
Authors: A Guentsch; C Hirsch; W Pfister; B Vincents; M Abrahamson; A Sroka; J Potempa; S Eick Journal: J Periodontal Res Date: 2012-11-01 Impact factor: 4.419
Authors: Elerson Gaetti-Jardim; Luis Fernando Landucci; Kathlenn Liezbeth de Oliveira; Iracy Costa; Robson Varlei Ranieri; Ana Cláudia Okamoto; Christiane Marie Schweitzer Journal: Int J Dent Date: 2012-07-08