BACKGROUND: Photodynamic therapy (PDT) is a non-invasive method for topical and selective treatment of pre-malignant lesions of oral cavity. The aim of our study was to determine therapeutic response to PDT in patients with oral leukoplakia. METHODS: Twelve patients participated in our study. Lesions affected a variety of intraoral sites. The most common location was buccal, gingival and mandibular mucosa. Patients were treated with topically applied 10% delta-aminolevulinic acid (ALA) and light from an argon-pumped dye laser. Irradiation was performed in several (6-8) sessions using light at 635 nm wavelength, delivering a total dose of 100 J/cm2 per session. RESULTS: A complete response was obtained in 10 out of 12 treated patients. One recurrence was observed during 6 months. CONCLUSION: Photodynamic therapy appears to be a feasible alternative to conventional therapy of pre-malignant lesions of oral cavity.
BACKGROUND: Photodynamic therapy (PDT) is a non-invasive method for topical and selective treatment of pre-malignant lesions of oral cavity. The aim of our study was to determine therapeutic response to PDT in patients with oral leukoplakia. METHODS: Twelve patients participated in our study. Lesions affected a variety of intraoral sites. The most common location was buccal, gingival and mandibular mucosa. Patients were treated with topically applied 10% delta-aminolevulinic acid (ALA) and light from an argon-pumped dye laser. Irradiation was performed in several (6-8) sessions using light at 635 nm wavelength, delivering a total dose of 100 J/cm2 per session. RESULTS: A complete response was obtained in 10 out of 12 treated patients. One recurrence was observed during 6 months. CONCLUSION: Photodynamic therapy appears to be a feasible alternative to conventional therapy of pre-malignant lesions of oral cavity.
Authors: Harry Quon; Craig E Grossman; Jarod C Finlay; Timothy C Zhu; Clarice S Clemmens; Kelly M Malloy; Theresa M Busch Journal: Photodiagnosis Photodyn Ther Date: 2011-06 Impact factor: 3.631
Authors: Peter H Ahn; Jarod C Finlay; Shannon M Gallagher-Colombo; Harry Quon; Bert W O'Malley; Gregory S Weinstein; Ara Chalian; Kelly Malloy; Thomas Sollecito; Martin Greenberg; Charles B Simone; Sally McNulty; Alexander Lin; Timothy C Zhu; Virginia Livolsi; Michael Feldman; Rosemarie Mick; Keith A Cengel; Theresa M Busch Journal: Photodiagnosis Photodyn Ther Date: 2017-11-04 Impact factor: 3.631
Authors: Stuart J Wong; Bruce Campbell; Becky Massey; Denis P Lynch; Ezra E W Cohen; Elizabeth Blair; Rebecca Selle; Julia Shklovskaya; Borko D Jovanovic; Silvia Skripkauskas; Alexander Dew; Peter Kulesza; Vamsi Parimi; Raymond C Bergan; Eva Szabo Journal: Oral Oncol Date: 2013-07-08 Impact factor: 5.337