H-2 associated differences in the weight of some androgen influenced organs in (C57BL/10ScSnPh X AKR/J) F2 individuals.

We have followed the possible influence of H-2 system on the differences in the relative weights of testes, vesicular gland and thymus in animals of a segregating (B10 X AKR) F2 generation. H-2b/H-2b male mice had significantly higher values of relative vesicular gland weight and significantly lower values of relative testes weight than H-2k/H-2k males. No differences in the relative thymus weight were found between these two groups of animals. The differences are caused by a complex effect of the H.2 associated genetic factor(s) because they influence simultaneously the body weight and the organ weights, the two indicators being mutually dependent to some extent.