Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Stretching and visualizing titin molecules: combining structure, dynamics and mechanics.

Literature DB >> 12785100

Stretching and visualizing titin molecules: combining structure, dynamics and mechanics.

Abstract

The details of the global and local structure and function of titin, a giant filamentous intrasarcomeric protein are largely undiscovered. Here we discuss a combination of bulk-solution and novel single-molecule techniques that may lend unique insights into titin's molecular dynamic, structural and mechanical characteristics.

Entities: Gene

Mesh：

Substances：

Year: 2002 PMID： 12785100 DOI： 10.1023/a:1023414624092

Source DB: PubMed Journal: J Muscle Res Cell Motil ISSN： 0142-4319 Impact factor: 2.698

58 in total

1. Fluorescence quenching: A tool for single-molecule protein-folding study.

Authors: X Zhuang; T Ha; H D Kim; T Centner; S Labeit; S Chu
Journal: Proc Natl Acad Sci U S A Date: 2000-12-19 Impact factor: 11.205

Review 2. Titin: a molecular control freak.

Authors: J Trinick; L Tskhovrebova
Journal: Trends Cell Biol Date: 1999-10 Impact factor: 20.808

3. Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.

Authors: A Freiburg; K Trombitas; W Hell; O Cazorla; F Fougerousse; T Centner; B Kolmerer; C Witt; J S Beckmann; C C Gregorio; H Granzier; S Labeit
Journal: Circ Res Date: 2000-06-09 Impact factor: 17.367

4. Extensibility in the titin molecule and its relation to muscle elasticity.

Authors: L Tskhovrebova; J Trinick
Journal: Adv Exp Med Biol Date: 2000 Impact factor: 2.622

5. PEVK domain of titin: an entropic spring with actin-binding properties.

Authors: Wolfgang A Linke; Michael Kulke; Hongbin Li; Setsuko Fujita-Becker; Ciprian Neagoe; Dietmar J Manstein; Mathias Gautel; Julio M Fernandez
Journal: J Struct Biol Date: 2002 Jan-Feb Impact factor: 2.867

Review 6. Role of titin in vertebrate striated muscle.

Authors: L Tskhovrebova; J Trinick
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2002-02-28 Impact factor: 6.237

7. Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments.

Authors: K Trombitás; M Greaser; S Labeit; J P Jin; M Kellermayer; M Helmes; H Granzier
Journal: J Cell Biol Date: 1998-02-23 Impact factor: 10.539

8. Elasticity and unfolding of single molecules of the giant muscle protein titin.

Authors: L Tskhovrebova; J Trinick; J A Sleep; R M Simmons
Journal: Nature Date: 1997-05-15 Impact factor: 49.962

Review 9. Muscle assembly: a titanic achievement?

Authors: C C Gregorio; H Granzier; H Sorimachi; S Labeit
Journal: Curr Opin Cell Biol Date: 1999-02 Impact factor: 8.382

10. The assembly of immunoglobulin-like modules in titin: implications for muscle elasticity.

Authors: S Improta; J K Krueger; M Gautel; R A Atkinson; J F Lefèvre; S Moulton; J Trewhella; A Pastore
Journal: J Mol Biol Date: 1998-12-04 Impact factor: 5.469

8 in total

1. A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain.

Authors: Eleonore von Castelmur; Marco Marino; Dmitri I Svergun; Laurent Kreplak; Zöhre Ucurum-Fotiadis; Petr V Konarev; Alexandre Urzhumtsev; Dietmar Labeit; Siegfried Labeit; Olga Mayans
Journal: Proc Natl Acad Sci U S A Date: 2008-01-22 Impact factor: 11.205

Stretching and visualizing titin molecules: combining structure, dynamics and mechanics.

1. Fluorescence quenching: A tool for single-molecule protein-folding study.

Review 2. Titin: a molecular control freak.

3. Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.

4. Extensibility in the titin molecule and its relation to muscle elasticity.

5. PEVK domain of titin: an entropic spring with actin-binding properties.

Review 6. Role of titin in vertebrate striated muscle.

7. Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments.

8. Elasticity and unfolding of single molecules of the giant muscle protein titin.

Review 9. Muscle assembly: a titanic achievement?

10. The assembly of immunoglobulin-like modules in titin: implications for muscle elasticity.

1. A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain.

2. S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.

3. High hydrostatic pressure induces slow contraction in mouse cardiomyocytes.

4. Damped elastic recoil of the titin spring in myofibrils of human myocardium.

Review 5. Forcing a connection: impacts of single-molecule force spectroscopy on in vivo tension sensing.

6. Multiscale mechanobiology: mechanics at the molecular, cellular, and tissue levels.

Review 7. Novel ncRNAs transcribed by Pol III and elucidation of their functional relevance by biophysical approaches.

Review 8. S-glutathionylation, friend or foe in cardiovascular health and disease.