Literature DB >> 12784628

Transepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers.

Yutaka Konishi1, Makoto Shimizu.   

Abstract

Our previous study (Biosci. Biotechnol. Biochem., 66, 2449-2457 (2002)), suggested that ferulic acid was transported via a monocarboxylic acid transporter (MCT). Transepithelial transport of ferulic acid was examined in this study by directly measuring the rate of its transport across Caco-2 cell monolayers. Ferulic acid transport was dependent on pH, and in a vectorical way in the apical-basolateral direction. The permeation of ferulic acid was concentration-dependent and saturable; the Michaelis constant was 16.2 mM and the maximum velocity was 220.4 nmol min-1 (mg protein)-1. Various substrates for MCTs, such as benzoic acid and acetic acid, strongly inhibited the permeation of ferulic acid, demonstrating that ferulic acid is obviously transported by MCT. Antioxidative phenolic acid compounds from dietary sources like ferulic acid would be recognized and transported by MCT by intestinal absorption.

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Year:  2003        PMID： 12784628     DOI： 10.1271/bbb.67.856

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  14 in total

1.  Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix.

Authors:  L Tesoriere; C Gentile; F Angileri; A Attanzio; M Tutone; M Allegra; M A Livrea
Journal:  Eur J Nutr       Date:  2012-07-18       Impact factor: 5.614

2.  Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells.

Authors:  Gavirangappa Hithamani; Dhanya Kizhakayil; Krishnapura Srinivasan
Journal:  J Biosci       Date:  2017-12       Impact factor: 1.826

3.  The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites.

Authors:  M Silberberg; C Morand; T Mathevon; C Besson; C Manach; A Scalbert; C Remesy
Journal:  Eur J Nutr       Date:  2005-06-30       Impact factor: 5.614

4.  Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4).

Authors:  Kerstin Ziegler; Asimina Kerimi; Laure Poquet; Gary Williamson
Journal:  Arch Biochem Biophys       Date:  2016-02-09       Impact factor: 4.013

5.  Safety profile of solid lipid nanoparticles loaded with rosmarinic acid for oral use: in vitro and animal approaches.

Authors:  Ana Raquel Madureira; Sara Nunes; Débora A Campos; João C Fernandes; Cláudia Marques; Monica Zuzarte; Beatriz Gullón; Luís M Rodríguez-Alcalá; Conceição Calhau; Bruno Sarmento; Ana Maria Gomes; Maria Manuela Pintado; Flávio Reis
Journal:  Int J Nanomedicine       Date:  2016-08-04

Review 6.  Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites--a position paper focusing on carotenoids and polyphenols.

Authors:  Torsten Bohn; Gordon J McDougall; Amparo Alegría; Marie Alminger; Eva Arrigoni; Anna-Marja Aura; Catarina Brito; Antonio Cilla; Sedef N El; Sibel Karakaya; Marie C Martínez-Cuesta; Claudia N Santos
Journal:  Mol Nutr Food Res       Date:  2015-06-03       Impact factor: 5.914

7.  Absorption and Metabolism of Phenolics from Digests of Polyphenol-Rich Potato Extracts Using the Caco-2/HepG2 Co-Culture System.

Authors:  Shima Sadeghi Ekbatan; Michele M Iskandar; Lekha Sleno; Kebba Sabally; Joelle Khairallah; Satya Prakash; Stan Kubow
Journal:  Foods       Date:  2018-01-12

8.  Chronic exposure to short-chain fatty acids modulates transport and metabolism of microbiome-derived phenolics in human intestinal cells.

Authors:  Evelien Van Rymenant; László Abrankó; Sarka Tumova; Charlotte Grootaert; John Van Camp; Gary Williamson; Asimina Kerimi
Journal:  J Nutr Biochem       Date:  2016-09-30       Impact factor: 6.048

Review 9.  Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further.

Authors:  Maria Carolina Rodríguez-Daza; Elena C Pulido-Mateos; Joseph Lupien-Meilleur; Denis Guyonnet; Yves Desjardins; Denis Roy
Journal:  Front Nutr       Date:  2021-06-28

10.  Permeability Study of Polyphenols Derived from a Phenolic-Enriched Hibiscus sabdariffa Extract by UHPLC-ESI-UHR-Qq-TOF-MS.

Authors:  Isabel Borrás-Linares; María Herranz-López; Enrique Barrajón-Catalán; David Arráez-Román; Isabel González-Álvarez; Marival Bermejo; Alberto Fernández Gutiérrez; Vicente Micol; Antonio Segura-Carretero
Journal:  Int J Mol Sci       Date:  2015-08-07       Impact factor: 5.923
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