AIM: The current study determines the MRI correlations of the early neuropsychological post-stroke cognitive deficits. METHOD: Detailed neuropsychological assessments (attention and working memory) were undertaken in 50 stroke survivors >75 years of age [38 with ageing-associated cognitive decline (AACD)] and 15 age-matched controls. A 1.5-tesla General Electric MRI scanner was used. Standardized visual ratings were undertaken of white matter hyperintensities (WMH). Grey matter volumes were assessed using voxel-based morphometery. RESULTS: Associations were identified between processing speed and executive function and the severity of WMH in key areas. In addition, atrophy in the fronto-subcortical circuits was associated with AACD. CONCLUSION: Attentional and executive impairments are underpinned by WMH in fronto-striato-thalamo-frontal circuits. Frontal atrophy is identified as a novel substrate of cognitive decline in stroke patients. Copyright 2003 S. Karger AG, Basel
AIM: The current study determines the MRI correlations of the early neuropsychological post-stroke cognitive deficits. METHOD: Detailed neuropsychological assessments (attention and working memory) were undertaken in 50 stroke survivors >75 years of age [38 with ageing-associated cognitive decline (AACD)] and 15 age-matched controls. A 1.5-tesla General Electric MRI scanner was used. Standardized visual ratings were undertaken of white matter hyperintensities (WMH). Grey matter volumes were assessed using voxel-based morphometery. RESULTS: Associations were identified between processing speed and executive function and the severity of WMH in key areas. In addition, atrophy in the fronto-subcortical circuits was associated with AACD. CONCLUSION: Attentional and executive impairments are underpinned by WMH in fronto-striato-thalamo-frontal circuits. Frontal atrophy is identified as a novel substrate of cognitive decline in strokepatients. Copyright 2003 S. Karger AG, Basel
Authors: Hanna Jokinen; Charlotte Ryberg; Hely Kalska; Raija Ylikoski; Egill Rostrup; Mikkel B Stegmann; Gunhild Waldemar; Sofia Madureira; José M Ferro; Elizabeth C W van Straaten; Philip Scheltens; Frederik Barkhof; Franz Fazekas; Reinhold Schmidt; Giovanna Carlucci; Leonardo Pantoni; Domenico Inzitari; Timo Erkinjuntti Journal: J Neurol Neurosurg Psychiatry Date: 2006-10-06 Impact factor: 10.154
Authors: H Jokinen; H Kalska; R Mäntylä; R Ylikoski; M Hietanen; T Pohjasvaara; M Kaste; T Erkinjuntti Journal: J Neurol Neurosurg Psychiatry Date: 2005-09 Impact factor: 10.154
Authors: Michael J Firbank; Louise M Allan; Emma J Burton; Robert Barber; John T O'Brien; Raj N Kalaria Journal: J Neurol Neurosurg Psychiatry Date: 2011-11-23 Impact factor: 10.154