Literature DB >> 12783429

Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis.

Ilias G Kirkinezos1, Dayami Hernandez, Walter G Bradley, Carlos T Moraes.   

Abstract

We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.

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Year:  2003        PMID： 12783429     DOI： 10.1002/ana.10597

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  47 in total

Review 1.  Neuroprotection for amyotrophic lateral sclerosis: role of stem cells, growth factors, and gene therapy.

Authors:  Rachna S Pandya; Lilly L J Mao; Edward W Zhou; Robert Bowser; Zhenglun Zhu; Yongjin Zhu; Xin Wang
Journal:  Cent Nerv Syst Agents Med Chem       Date:  2012-03

2.  Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis.

Authors:  Timothy M Miller; Soo H Kim; Koji Yamanaka; Mark Hester; Priya Umapathi; Hannah Arnson; Liza Rizo; Jerry R Mendell; Fred H Gage; Don W Cleveland; Brian K Kaspar
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-12       Impact factor: 11.205

3.  Long-term exercise-specific neuroprotection in spinal muscular atrophy-like mice.

Authors:  Farah Chali; Céline Desseille; Léo Houdebine; Evelyne Benoit; Thaïs Rouquet; Bruno Bariohay; Philippe Lopes; Julien Branchu; Bruno Della Gaspera; Claude Pariset; Christophe Chanoine; Frédéric Charbonnier; Olivier Biondi
Journal:  J Physiol       Date:  2016-02-27       Impact factor: 5.182

Review 4.  Perspectives on clinical trials in spinal muscular atrophy.

Authors:  Kathryn J Swoboda; John T Kissel; Thomas O Crawford; Mark B Bromberg; Gyula Acsadi; Guy D'Anjou; Kristin J Krosschell; Sandra P Reyna; Mary K Schroth; Charles B Scott; Louise R Simard
Journal:  J Child Neurol       Date:  2007-08       Impact factor: 1.987

5.  Effects of Tongue Force Training on Bulbar Motor Function in the Female SOD1-G93A Rat Model of Amyotrophic Lateral Sclerosis.

Authors:  Delin Ma; Jeffrey M Shuler; Aishwarya Kumar; Quincy R Stanford; Sudheer Tungtur; Hiroshi Nishimune; John A Stanford
Journal:  Neurorehabil Neural Repair       Date:  2016-09-24       Impact factor: 3.919

6.  Moderate exercise delays the motor performance decline in a transgenic model of ALS.

Authors:  Isabel Carreras; Sinan Yuruker; Nurgul Aytan; Lokman Hossain; Ji-Kyung Choi; Bruce G Jenkins; Neil W Kowall; Alpaslan Dedeoglu
Journal:  Brain Res       Date:  2009-12-05       Impact factor: 3.252

Review 7.  Physical activity and neuroprotection in amyotrophic lateral sclerosis.

Authors:  Mary E McCrate; Brian K Kaspar
Journal:  Neuromolecular Med       Date:  2008-02-20       Impact factor: 3.843

8.  Motoneuron survival is promoted by specific exercise in a mouse model of amyotrophic lateral sclerosis.

Authors:  Séverine Deforges; Julien Branchu; Olivier Biondi; Clément Grondard; Claude Pariset; Sylvie Lécolle; Philippe Lopes; Pierre-Paul Vidal; Christophe Chanoine; Frédéric Charbonnier
Journal:  J Physiol       Date:  2009-06-02       Impact factor: 5.182

9.  Pre-symptomatic detection of chronic motor deficits and genotype prediction in congenic B6.SOD1(G93A) ALS mouse model.

Authors:  C R Hayworth; F Gonzalez-Lima
Journal:  Neuroscience       Date:  2009-08-20       Impact factor: 3.590

10.  A conditioning lesion provides selective protection in a rat model of Amyotrophic Lateral Sclerosis.

Authors:  Colin K Franz; Eric T Quach; Christina A Krudy; Thais Federici; Michele A Kliem; Brooke R Snyder; Bethwel Raore; Nicholas M Boulis
Journal:  PLoS One       Date:  2009-10-06       Impact factor: 3.240
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