BACKGROUND AND PURPOSE: The development of magnifying chromoendoscopy has facilitated the observation of mucosal pit patterns. This study investigated the value of this technology in predicting the histologic findings of colorectal lesions. METHODS: A total of 954 colorectal polyps were included. After identifying the lesions at colonoscopy, 0.2% indigocarmine solution was sprayed and then the zoom apparatus was switched to make a magnified view of the stained crypt orifice at a maximum 100 times magnification. The observed pit patterns were classified into 6 categories (I, II, IIIL, IIIS, IV, and V) according to Kudo's classification. Type I and II were designated as non-neoplastic patterns whereas other types were neoplastic. Correlation of the pit pattern with the findings of histologic examinations of resected or biopsied polyps was performed. RESULTS: There were 678 diminutive (</= 5 mm) polyps (71.1%) and 705 neoplastic polyps (73.9%), including 695 adenomas and 10 carcinomas. When comparing histologically confirmed neoplastic lesions to non-neoplastic lesions, prediction of neoplastic lesions by endoscopists based on magnifying chromoendoscopy had a sensitivity of 90.8%, a specificity of 72.7%, a positive predictive value of 90.4%, a negative predictive value of 73.6%, and an overall accuracy of 86.1%. The diagnostic accuracy for neoplastic lesions was not associated with polyp size and location but was related to the operator's experience. CONCLUSIONS: Characteristic pit patterns obtained by magnifying chromoendoscopy provide useful clues for differentiation of adenomatous from non-adenomatous polyps. Used appropriately in experienced hands, this technique offers a valuable adjunct to standard colonoscopy in predicting the histologic characteristics of colorectal polyps.
BACKGROUND AND PURPOSE: The development of magnifying chromoendoscopy has facilitated the observation of mucosal pit patterns. This study investigated the value of this technology in predicting the histologic findings of colorectal lesions. METHODS: A total of 954 colorectal polyps were included. After identifying the lesions at colonoscopy, 0.2% indigocarmine solution was sprayed and then the zoom apparatus was switched to make a magnified view of the stained crypt orifice at a maximum 100 times magnification. The observed pit patterns were classified into 6 categories (I, II, IIIL, IIIS, IV, and V) according to Kudo's classification. Type I and II were designated as non-neoplastic patterns whereas other types were neoplastic. Correlation of the pit pattern with the findings of histologic examinations of resected or biopsied polyps was performed. RESULTS: There were 678 diminutive (</= 5 mm) polyps (71.1%) and 705 neoplastic polyps (73.9%), including 695 adenomas and 10 carcinomas. When comparing histologically confirmed neoplastic lesions to non-neoplastic lesions, prediction of neoplastic lesions by endoscopists based on magnifying chromoendoscopy had a sensitivity of 90.8%, a specificity of 72.7%, a positive predictive value of 90.4%, a negative predictive value of 73.6%, and an overall accuracy of 86.1%. The diagnostic accuracy for neoplastic lesions was not associated with polyp size and location but was related to the operator's experience. CONCLUSIONS: Characteristic pit patterns obtained by magnifying chromoendoscopy provide useful clues for differentiation of adenomatous from non-adenomatous polyps. Used appropriately in experienced hands, this technique offers a valuable adjunct to standard colonoscopy in predicting the histologic characteristics of colorectal polyps.
Authors: Carlos Augusto Real Martinez; Júlia Cutovoi; Debora Helena Rossi; Luciana Rodrigues Meirelles; Maria de Lourdes Setsuko Ayrizono; Raquel Franco Leal; Cláudio Saddy Rodrigues Coy Journal: Case Rep Surg Date: 2015-04-22