Literature DB >> 12782664

A new hypothesis for how sex steroid hormones regulate bone mass.

Joseph Lorenzo1.   

Abstract

It has been proposed - but remains controversial - that estrogen's effects on various tissues may be mediated by different cell signaling pathways. Researchers have identified a synthetic ligand that activates only a subset of these pathways, suggesting that bypass of the traditional estrogen pathway can prevent bone loss without associated side effects on reproductive organs.

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Year:  2003        PMID： 12782664      PMCID： PMC156115          DOI： 10.1172/JCI18812

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  16 in total

1.  Generation of bone-resorbing osteoclasts from B220+ cells: its role in accelerated osteoclastogenesis due to estrogen deficiency.

Authors:  T Sato; T Shibata; K Ikeda; K Watanabe
Journal:  J Bone Miner Res       Date:  2001-12       Impact factor: 6.741

2.  Endocrinology. Divorcing estrogen's bright and dark sides.

Authors:  Greg Miller
Journal:  Science       Date:  2002-10-25       Impact factor: 47.728

3.  Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites.

Authors:  K Paech; P Webb; G G Kuiper; S Nilsson; J Gustafsson; P J Kushner; T S Scanlan
Journal:  Science       Date:  1997-09-05       Impact factor: 47.728

Review 4.  Oestrogen receptors, receptor variants and oestrogen actions in the hypothalamic-pituitary axis.

Authors:  M A Shupnik
Journal:  J Neuroendocrinol       Date:  2002-02       Impact factor: 3.627

5.  Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.

Authors:  B Saville; M Wormke; F Wang; T Nguyen; E Enmark; G Kuiper; J A Gustafsson; S Safe
Journal:  J Biol Chem       Date:  2000-02-25       Impact factor: 5.157

6.  Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity.

Authors:  S Kousteni; T Bellido; L I Plotkin; C A O'Brien; D L Bodenner; L Han; K Han; G B DiGregorio; J A Katzenellenbogen; B S Katzenellenbogen; P K Roberson; R S Weinstein; R L Jilka; S C Manolagas
Journal:  Cell       Date:  2001-03-09       Impact factor: 41.582

7.  Connection between B lymphocyte and osteoclast differentiation pathways.

Authors:  N Manabe; H Kawaguchi; H Chikuda; C Miyaura; M Inada; R Nagai; Y Nabeshima ; K Nakamura; A M Sinclair; R H Scheuermann; M Kuro-o
Journal:  J Immunol       Date:  2001-09-01       Impact factor: 5.422

8.  Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.

Authors:  E J Filardo; J A Quinn; K I Bland; A R Frackelton
Journal:  Mol Endocrinol       Date:  2000-10

Review 9.  Rapid actions of steroid receptors in cellular signaling pathways.

Authors:  Andrew C B Cato; Andrea Nestl; Sigrun Mink
Journal:  Sci STKE       Date:  2002-06-25

10.  Reversal of bone loss in mice by nongenotropic signaling of sex steroids.

Authors:  S Kousteni; J R Chen; T Bellido; L Han; A A Ali; C A O'Brien; L Plotkin; Q Fu; A T Mancino; Y Wen; A M Vertino; C C Powers; S A Stewart; R Ebert; A M Parfitt; R S Weinstein; R L Jilka; S C Manolagas
Journal:  Science       Date:  2002-10-25       Impact factor: 47.728
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  6 in total

Review 1.  Endocrine disrupting compounds and echinoderms: new ecotoxicological sentinels for the marine ecosystem.

Authors:  Michela Sugni; Daniela Mozzi; Alice Barbaglio; Francesco Bonasoro; Maria Daniela Candia Carnevali
Journal:  Ecotoxicology       Date:  2007-02       Impact factor: 2.823

2.  G-protein-coupled receptor 30 mediates estrogen's nongenomic effects after hemorrhagic shock and trauma.

Authors:  Daniel R Meldrum
Journal:  Am J Pathol       Date:  2007-04       Impact factor: 4.307

3.  Chemical fate and biological effects of several endocrine disrupters compounds in two echinoderm species.

Authors:  Michela Sugni; Paolo Tremolada; Cinta Porte; Alice Barbaglio; Francesco Bonasoro; M Daniela Candia Carnevali
Journal:  Ecotoxicology       Date:  2010-03       Impact factor: 2.823

4.  Dose-dependent regulation of cell proliferation and collagen degradation by estradiol on ligamentum flavum.

Authors:  Mei-Hsiu Chen; Chao-Kai Hu; Pei-Ru Chen; Yu-Shan Chen; Jui-Sheng Sun; Ming-Hong Chen
Journal:  BMC Musculoskelet Disord       Date:  2014-07-15       Impact factor: 2.362

Review 5.  Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review.

Authors:  Gamal Abdel Nasser Atia; Hany K Shalaby; Mehrukh Zehravi; Mohamed Mohamady Ghobashy; Zubair Ahmad; Farhat S Khan; Abhijit Dey; Md Habibur Rahman; Sang Woo Joo; Hasi Rani Barai; Simona Cavalu
Journal:  Polymers (Basel)       Date:  2022-07-21       Impact factor: 4.967

6.  Different effects of total flavonoids from Arachniodes exilis on human umbilical cord mesenchymal stem cells in vitro.

Authors:  Wenmin Yu; Wenlong Hu; Xiumei Ke; Xufeng Zhou; Changchang Yin; Ming Yin
Journal:  Medicine (Baltimore)       Date:  2020-06-19       Impact factor: 1.817
  6 in total

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