Literature DB >> 12782573

Magnetic resonance molecular imaging of the HER-2/neu receptor.

Dmitri Artemov1, Noriko Mori, Rajani Ravi, Zaver M Bhujwalla.   

Abstract

The HER-2/neu receptor is a member of the epidermal growth factor family and is amplified in multiple cancers. It is under intense investigation both as a prognostic marker and for therapy, using monoclonal antibodies targeted against the receptor. We have developed a novel two-component gadolinium-based MR contrast agent to image the HER-2/neu receptor. Positive T1 contrast in MR images was generated by the specific binding of avidin-gadolinium complexes to tumor cells prelabeled with a biotinylated anti-HER-2/neu antibody. Significant intensity enhancement was observed in HER-2/neu-expressing cell lines and in vivo in a breast cancer model. Potential applications of this approach may include determination of the HER-2/neu status for prognosis and for selecting tumors for monoclonal antibody therapy.

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Year:  2003        PMID： 12782573

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  69 in total

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8.  Multiparametric monitoring of tumor response to chemotherapy by noninvasive imaging.

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9.  Molecular Imaging of Cancer: Applications of Magnetic Resonance Methods.

Authors:  Barjor Gimi; Arvind P Pathak; Ellen Ackerstaff; Kristine Glunde; Dmitri Artemov; Zaver M Bhujwalla
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10.  An immunotolerant HER-2/neu transgenic mouse model of metastatic breast cancer.

Authors:  Hong Song; Karineh Shahverdi; David L Huso; Yuchuan Wang; James J Fox; Robert F Hobbs; Barjor Gimi; Kathleen L Gabrielson; Martin G Pomper; Benjamin M Tsui; Zaver Bhujwalla; R Todd Reilly; George Sgouros
Journal:  Clin Cancer Res       Date:  2008-10-01       Impact factor: 12.531
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