Literature DB >> 12782396

DNA damage in brain cells of mice treated with an oxidized form of apomorphine.

Jaqueline Nascimento Picada1, Debora G Flores, Cláudio G Zettler, Norma Possa Marroni, Rafael Roesler, João Antonio Pêgas Henriques.   

Abstract

We investigated whether systemic injection of apomorphine and its oxidation derivative 8-oxo-apomorphine-semiquinone (8-OASQ) could induce DNA damage in mice brain, using the single-cell gel assay. 8-OASQ induced DNA damage in the brains at 1 and 3 h, but not at 24 h after treatment whereas apomorphine induced a slight increase in brain DNA damage frequency at 3 h after treatment, suggesting that both drugs display genotoxic activity in brain tissue.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12782396     DOI： 10.1016/s0169-328x(03)00127-x

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  12 in total

1.  Genotoxicity associated with oxidative damage in the liver and kidney of mice exposed to dimethoate subchronic intoxication.

Authors:  Imen Ayed-Boussema; Karima Rjiba; Amal Moussa; Nourhène Mnasri; Hassen Bacha
Journal:  Environ Sci Pollut Res Int       Date:  2011-08-07       Impact factor: 4.223

2.  Crocin protects the liver and kidney from patulin-induced apoptosis in vivo.

Authors:  Manel Boussabbeh; Intidhar Ben Salem; Faicel Belguesmi; Fadwa Neffati; Mohamed Fadhel Najjar; Salwa Abid-Essefi; Hassen Bacha
Journal:  Environ Sci Pollut Res Int       Date:  2016-02-09       Impact factor: 4.223

3.  Neurobehavioral and genotoxic parameters of antipsychotic agent aripiprazole in mice.

Authors:  Jaqueline Nascimento Picada; Bruna de Jesus Neto Dos Santos; Franciele Celso; Jéssica Dias Monteiro; Kelly Morais Da Rosa; Leandro Rosa Camacho; Luciana Rodrigues Vieira; Taís Madelon Freitas; Tatiana Grasiela Da Silva; Viviane Minuzzo Pontes; Patrícia Pereira
Journal:  Acta Pharmacol Sin       Date:  2011-08-15       Impact factor: 6.150

4.  Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats.

Authors:  Hanen Ferjani; Amira El Arem; Aicha Bouraoui; Abedellatif Achour; Salwa Abid; Hassen Bacha; Imen Boussema-Ayed
Journal:  J Physiol Biochem       Date:  2016-01-09       Impact factor: 4.158

5.  Neurobehavioral effects of vigabatrin and its ability to induce DNA damage in brain cells after acute treatment in rats.

Authors:  Karen Sousa; Natalia Decker; Thienne Rocha Pires; Débora Kuck Mausolff Papke; Vanessa Rodrigues Coelho; Pricila Pflüger; Patrícia Pereira; Jaqueline Nascimento Picada
Journal:  Psychopharmacology (Berl)       Date:  2016-09-27       Impact factor: 4.530

6.  N-acetylcysteine modulates angiogenesis and vasodilation in stomach such as DNA damage in blood of portal hypertensive rats.

Authors:  Francielli Licks; Renata Minuzzo Hartmann; Camila Marques; Elizângela Schemitt; Josieli Raskopf Colares; Mariana do Couto Soares; Juliana Reys; Camila Fisher; Juliana da Silva; Norma Possa Marroni
Journal:  World J Gastroenterol       Date:  2015-11-21       Impact factor: 5.742

7.  Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson's disease mice model.

Authors:  Tarek K Motawi; Nermin A H Sadik; Manal A Hamed; Sanaa A Ali; Wagdy K B Khalil; Yomna R Ahmed
Journal:  Mol Cell Biochem       Date:  2019-12-09       Impact factor: 3.396

8.  Beneficial effects of mycophenolate mofetil on cardiotoxicity induced by tacrolimus in wistar rats.

Authors:  Hanen Ferjani; Rim Timoumi; Ines Amara; Salwa Abid; Abedellatif Achour; Hassen Bacha; Imen Boussema-Ayed
Journal:  Exp Biol Med (Maywood)       Date:  2016-07-24

9.  Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice.

Authors:  Paulo Alexandre de Oliveira; Felipe Luis Lino; Shandale Emanuele Cappelari; Lucimar Filot da Silva Brum; Jaqueline Nascimento Picada; Patrícia Pereira
Journal:  Exp Brain Res       Date:  2008-02-05       Impact factor: 1.972

10.  Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure.

Authors:  Darlan P Rosa; Denis Martinez; Jaqueline N Picada; Juliane G Semedo; Norma P Marroni
Journal:  Comp Hepatol       Date:  2011-07-05
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.