Literature DB >> 12782285

The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction.

Dieter Rosskopf1, Christiane Nikula, Iris Manthey, Markus Joisten, Ulrich Frey, Stefanie Kohnen, Winfried Siffert.   

Abstract

The aim of this study was the characterization of the human Gbeta4 subunit of heterotrimeric G proteins. Human Gbeta4 is widely expressed. Its gene is located on chromosome 3 with a genomic structure indistinguishable from that of the genes of Gbeta1 to Gbeta3, but entirely different from Gbeta5. In vitro translation co-precipitation analyses revealed that Gbeta4 can form stable dimers with Ggamma1, Ggamma2, Ggamma3, Ggamma4, Ggamma5, Ggamma7, Ggamma10, Ggamma11, Ggamma12, and Ggamma13, dimers which were also able to stimulate phospholipase beta2.

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Year:  2003        PMID： 12782285     DOI： 10.1016/s0014-5793(03)00441-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Genome-wide association analysis identifies multiple loci related to resting heart rate.

Authors:  Mark Eijgelsheim; Christopher Newton-Cheh; Nona Sotoodehnia; Paul I W de Bakker; Martina Müller; Alanna C Morrison; Albert V Smith; Aaron Isaacs; Serena Sanna; Marcus Dörr; Pau Navarro; Christian Fuchsberger; Ilja M Nolte; Eco J C de Geus; Karol Estrada; Shih-Jen Hwang; Joshua C Bis; Ina-Maria Rückert; Alvaro Alonso; Lenore J Launer; Jouke Jan Hottenga; Fernando Rivadeneira; Peter A Noseworthy; Kenneth M Rice; Siegfried Perz; Dan E Arking; Tim D Spector; Jan A Kors; Yurii S Aulchenko; Kirill V Tarasov; Georg Homuth; Sarah H Wild; Fabio Marroni; Christian Gieger; Carmilla M Licht; Ronald J Prineas; Albert Hofman; Jerome I Rotter; Andrew A Hicks; Florian Ernst; Samer S Najjar; Alan F Wright; Annette Peters; Ervin R Fox; Ben A Oostra; Heyo K Kroemer; David Couper; Henry Völzke; Harry Campbell; Thomas Meitinger; Manuela Uda; Jacqueline C M Witteman; Bruce M Psaty; H-Erich Wichmann; Tamara B Harris; Stefan Kääb; David S Siscovick; Yalda Jamshidi; André G Uitterlinden; Aaron R Folsom; Martin G Larson; James F Wilson; Brenda W Penninx; Harold Snieder; Peter P Pramstaller; Cornelia M van Duijn; Edward G Lakatta; Stephan B Felix; Vilmundur Gudnason; Arne Pfeufer; Susan R Heckbert; Bruno H Ch Stricker; Eric Boerwinkle; Christopher J O'Donnell
Journal:  Hum Mol Genet       Date:  2010-07-16       Impact factor: 6.150

Review 2.  Structural determinants involved in the formation and activation of G protein betagamma dimers.

Authors:  William E McIntire
Journal:  Neurosignals       Date:  2009-02-12

3.  Exome sequencing identifies GNB4 mutations as a cause of dominant intermediate Charcot-Marie-Tooth disease.

Authors:  Bing-Wen Soong; Yen-Hua Huang; Pei-Chien Tsai; Chien-Chang Huang; Hung-Chuan Pan; Yi-Chun Lu; Hsin-Ju Chien; Tze-Tze Liu; Ming-Hong Chang; Kon-Ping Lin; Pang-Hsien Tu; Lung-Sen Kao; Yi-Chung Lee
Journal:  Am J Hum Genet       Date:  2013-02-21       Impact factor: 11.025

4.  Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.

Authors:  Marta Garcia-Miralles; Michal Geva; Jing Ying Tan; Nur Amirah Binte Mohammad Yusof; Yoonjeong Cha; Rebecca Kusko; Liang Juin Tan; Xiaohong Xu; Iris Grossman; Aric Orbach; Michael R Hayden; Mahmoud A Pouladi
Journal:  JCI Insight       Date:  2017-12-07

5.  Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish.

Authors:  Timothy Mulligan; Heiko Blaser; Erez Raz; Steven A Farber
Journal:  Cell Signal       Date:  2009-09-26       Impact factor: 4.315

Review 6.  Subtype-dependent regulation of Gβγ signalling.

Authors:  Mithila Tennakoon; Kanishka Senarath; Dinesh Kankanamge; Kasun Ratnayake; Dhanushan Wijayaratna; Koshala Olupothage; Sithurandi Ubeysinghe; Kimberly Martins-Cannavino; Terence E Hébert; Ajith Karunarathne
Journal:  Cell Signal       Date:  2021-02-11       Impact factor: 4.850

7.  Identification of hub genes in chronically hypoxic myocardium using bioinformatics analysis.

Authors:  Fan Wu; Feng Gao; Siyi He; Yingbin Xiao
Journal:  Mol Med Rep       Date:  2019-03-01       Impact factor: 2.952

Review 8.  The Emerging Role of Gβ Subunits in Human Genetic Diseases.

Authors:  Natascia Malerba; Pasquelena De Nittis; Giuseppe Merla
Journal:  Cells       Date:  2019-12-04       Impact factor: 6.600
  8 in total

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