| Literature DB >> 12782073 |
Simone Wagner1, Mariana S Castro, João Alexandre R G Barbosa, Wagner Fontes, Elisabeth N F Schwartz, Antonio Sebben, Osmindo Rodrigues Pires, Marcelo V Sousa, Carlos Alberto Schwartz.
Abstract
In the present study Tityus fasciolatus crude venom toxicity was evaluated and we also report the purification and characterization of a 6.6 kDa neurotoxin isolated from T. fasciolatus venom. This new toxin, named Tf4, has a molecular mass of 6614Da and its primary structure is homologous to TbIT-I from T. bahiensis and TsTX-VI and TsNTxP from T. serrulatus. Tf4 delays frog sodium channel inactivation reversibly, but it is non-toxic to mammals or crustaceans. An attempt to identify the residues responsible for the partial loss of toxicity in Tf4 was carried out based on homology modeling and sequence comparison.Entities:
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Year: 2003 PMID： 12782073 DOI： 10.1016/s0041-0101(03)00008-4
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033