Literature DB >> 12781805

Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki.

Jae-Ha Ryu1, Hanna Ahn, Hwa Jin Lee.   

Abstract

The ethyl acetate soluble fraction of Broussonetia kazinoki at 50 microg/ml showed a significant inhibition (78.2%) of nitric oxide (NO) in lipopolysaccharide activated macrophages. Kazinol B, an isoprenylated flavan, was identified as the active principle. It inhibits the NO synthesis with an IC(50) of 21.6 microM.

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Year:  2003        PMID： 12781805     DOI： 10.1016/s0367-326x(03)00062-5

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  13 in total

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Journal:  J Agric Food Chem       Date:  2009-11-25       Impact factor: 5.279

2.  Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils.

Authors:  Jih-Pyang Wang; Mei-Feng Hsu; Horng-Huey Ko; Chun-Nan Lin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-11-19       Impact factor: 3.000

3.  Anticancer and anti-inflammatory effects of cysteine metabolites of the green tea polyphenol, (-)-epigallocatechin-3-gallate.

Authors:  Joshua D Lambert; Shengmin Sang; Jungil Hong; Chung S Yang
Journal:  J Agric Food Chem       Date:  2010-09-22       Impact factor: 5.279

4.  Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced β-cell damage and the development of type 1 diabetes.

Authors:  Ui-Jin Bae; Hyun-Young Jang; Jung Min Lim; Li Hua; Jae-Ha Ryu; Byung-Hyun Park
Journal:  Exp Mol Med       Date:  2015-04-24       Impact factor: 8.718

5.  The Leaves of Broussonetia kazinoki Siebold Inhibit Atopic Dermatitis-Like Response on Mite Allergen-Treated Nc/Nga Mice.

Authors:  Hoyoung Lee; Hyekyung Ha; Jun Kyoung Lee; Sang-Joon Park; Seung-Ii Jeong; Hyeun Kyoo Shin
Journal:  Biomol Ther (Seoul)       Date:  2014-09-30       Impact factor: 4.634

6.  Prenylated Polyphenols from Broussonetia kazinoki as Inhibitors of Nitric Oxide Production.

Authors:  Da Yeon Lee; Hwa Jin Lee; Jae-Ha Ryu
Journal:  Molecules       Date:  2018-03-12       Impact factor: 4.411

7.  Protective Effects of Broussonetia kazinoki Siebold Fruit Extract against Palmitate-Induced Lipotoxicity in Mesangial Cells.

Authors:  Donghee Kim; Hyo-Jin Kim; Seon-Heui Cha; Hee-Sook Jun
Journal:  Evid Based Complement Alternat Med       Date:  2019-01-08       Impact factor: 2.629

8.  Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression.

Authors:  Jae Hyeon Kim; Sunho Kim; Surim Han; Eun-Kyung Ahn; Young-Rak Cho; Wonsik Jeong; Sung Joon Kim; Gyu-Un Bae; Joa Sub Oh; Dong-Wan Seo
Journal:  J Cell Mol Med       Date:  2022-01-06       Impact factor: 5.310

9.  Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation.

Authors:  Jae Min Lee; Sun Sil Choi; Mi Hyeon Park; Hyunduk Jang; Yo Han Lee; Keon Woo Khim; Sei Ryang Oh; Jiyoung Park; Hyung Won Ryu; Jang Hyun Choi
Journal:  Nutrients       Date:  2020-03-14       Impact factor: 5.717

10.  Prevention of Oxidative Stress-Induced Pancreatic Beta Cell Damage by Broussonetia Kazinoki Siebold Fruit Extract Via the ERK-Nox4 Pathway.

Authors:  Hyo-Jin Kim; Donghee Kim; Haelim Yoon; Cheol Soo Choi; Yoon Sin Oh; Hee-Sook Jun
Journal:  Antioxidants (Basel)       Date:  2020-05-10
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