Louis Yik-Si Chan1, Pui Yu Chiu, Tze Kin Lau. 1. Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Sing Street, Shatin, Hong Kong, China. lyschan@cuhk.edu.hk
Abstract
OBJECTIVE: To evaluate the effect of various antepartum conditions on cord blood thyroid-stimulating hormone (TSH) level. STUDY DESIGN: The study group consisted of 24,892 consecutive singleton deliveries over a period of 4 years. The effect of preeclampsia, glucose intolerance, maternal medical diseases, and antepartum hemorrhage of unknown origin (APHUO) on cord blood TSH level were assessed by univariate analysis and linear regression. RESULTS: After controlling for potential confounders, there was a significant independent association between cord blood TSH level and preeclampsia (P=0.043), glucose intolerance (P=0.015), and maternal medical diseases (P=0.022). Antepartum hemorrhage of unknown origin was not associated with a higher cord blood TSH level. CONCLUSION: Cord blood TSH level was significantly elevated in various adverse antepartum conditions. This may be related to the placental insufficiency and fetal hypoxia commonly found in these high-risk pregnancies.
OBJECTIVE: To evaluate the effect of various antepartum conditions on cord blood thyroid-stimulating hormone (TSH) level. STUDY DESIGN: The study group consisted of 24,892 consecutive singleton deliveries over a period of 4 years. The effect of preeclampsia, glucose intolerance, maternal medical diseases, and antepartum hemorrhage of unknown origin (APHUO) on cord blood TSH level were assessed by univariate analysis and linear regression. RESULTS: After controlling for potential confounders, there was a significant independent association between cord blood TSH level and preeclampsia (P=0.043), glucose intolerance (P=0.015), and maternal medical diseases (P=0.022). Antepartum hemorrhage of unknown origin was not associated with a higher cord blood TSH level. CONCLUSION: Cord blood TSH level was significantly elevated in various adverse antepartum conditions. This may be related to the placental insufficiency and fetal hypoxia commonly found in these high-risk pregnancies.
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