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Literature DB >> 12781360

Adoptive immunotherapy: engineering T cell responses as biologic weapons for tumor mass destruction.

William Y Ho¹, Joseph N Blattman, Michelle L Dossett, Cassian Yee, Philip D Greenberg.

Abstract

Adoptive T cell immunotherapy is an evolving technology with the potential of providing a means to safely and effectively target tumor cells for destruction.

Entities: Disease

Mesh：

Year: 2003 PMID： 12781360 DOI： 10.1016/s1535-6108(03)00113-2

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

Keyword Cloud
Cited

58 in total

1. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

Authors: Rachael D Aubert; Alice O Kamphorst; Surojit Sarkar; Vaiva Vezys; Sang-Jun Ha; Daniel L Barber; Lilin Ye; Arlene H Sharpe; Gordon J Freeman; Rafi Ahmed
Journal: Proc Natl Acad Sci U S A Date: 2011-12-12 Impact factor: 11.205

2. Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice.

Authors: Ingunn M Stromnes; Joseph N Blattman; Xiaoxia Tan; Sara Jeevanjee; Hua Gu; Philip D Greenberg
Journal: J Clin Invest Date: 2010-09-20 Impact factor: 14.808

3. Cancer immunotherapy using a bispecific NK receptor fusion protein that engages both T cells and tumor cells.

Authors: Tong Zhang; Charles L Sentman
Journal: Cancer Res Date: 2011-01-31 Impact factor: 12.701

4. Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma.

Authors: Ajay V Maker; James C Yang; Richard M Sherry; Suzanne L Topalian; Udai S Kammula; Richard E Royal; Marybeth Hughes; Michael J Yellin; Leah R Haworth; Catherine Levy; Tamika Allen; Sharon A Mavroukakis; Peter Attia; Steven A Rosenberg
Journal: J Immunother Date: 2006 Jul-Aug Impact factor: 4.456

Adoptive immunotherapy: engineering T cell responses as biologic weapons for tumor mass destruction.

1. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

2. Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice.

3. Cancer immunotherapy using a bispecific NK receptor fusion protein that engages both T cells and tumor cells.

4. Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma.

Review 5. New cell sources for T cell engineering and adoptive immunotherapy.

6. Redirecting adaptive immunity against foreign antigens to tumors for cancer therapy.

7. Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells.

8. Bcl-2 overexpression enhances tumor-specific T-cell survival.

Review 9. Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities.

10. Engineering higher affinity T cell receptors using a T cell display system.