OBJECTIVE: The present study examines the possible relationships between anxiety sensitivity (AS) and reactivity to the 35% carbon dioxide (CO(2)) challenge in panic disorder (PD). METHODS: One-hundred eight patients with PD underwent the 35% CO(2) challenge and completed the Anxiety Sensitivity Index (ASI). Multiple regression analyses were applied to evaluate the role of AS as a predictor of CO(2)-induced anxiety. RESULTS: Fifty-six patients with PD showed high AS scores, whereas 48 showed medium scores and 4 low scores. ASI scores significantly predicted symptomatological reaction to CO(2) but not subjective induced anxiety. CONCLUSION: These findings suggest that the fear of anxiety-related bodily sensations was related to the symptomatological reactivity to CO(2) but did not seem to play a crucial role in the modulation of the subjective anxiogenic/panicogenic response to hypercapnia in patients with PD.
OBJECTIVE: The present study examines the possible relationships between anxiety sensitivity (AS) and reactivity to the 35% carbon dioxide (CO(2)) challenge in panic disorder (PD). METHODS: One-hundred eight patients with PD underwent the 35% CO(2) challenge and completed the Anxiety Sensitivity Index (ASI). Multiple regression analyses were applied to evaluate the role of ASas a predictor of CO(2)-induced anxiety. RESULTS: Fifty-six patients with PD showed high AS scores, whereas 48 showed medium scores and 4 low scores. ASI scores significantly predicted symptomatological reaction to CO(2) but not subjective induced anxiety. CONCLUSION: These findings suggest that the fear of anxiety-related bodily sensations was related to the symptomatological reactivity to CO(2) but did not seem to play a crucial role in the modulation of the subjective anxiogenic/panicogenic response to hypercapnia in patients with PD.
Authors: Paul F Martino; Daniel P Miller; Justin R Miller; Michael T Allen; Denise R Cook-Snyder; Justin D Handy; Richard J Servatius Journal: Front Neurosci Date: 2020-11-13 Impact factor: 4.677